- S-HCL-1 (See other available formats)
- Other Names
- BL-CAM, Siglec-2, Lyb8
- Mouse IgG2b, κ
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- Product Citations
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CD22 is a 130 kD type I transmembrane glycoprotein also known as Siglec-2 and BL-CAM and is a member of the immunoglobulin superfamily (sialoadhesion subgroup). CD22 is expressed in the cytoplasm of pro-B and pre-B cells, and on the surface of mature B and activated B cells, but not on plasma cells. CD22 is present in the B cell receptor complex and associates with SHP-1, Syk, Lck, Lyn, and phospholipase Cγ1. A primary function of CD22 is thought to be in limiting antigen receptor signaling by modulating B cell activation threshold. CD22 has been shown to bind to CD45RO and CD75, although the natural ligands for this molecule remain controversial.Product Details
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
- Nitschke L. 2005. Curr. Opin. Immunol. 17:290
- Foon Ka, et al. 1986. Blood. 68:297
- Schwarting R, et al. 1985. Blood. 65:974
- Campana D, et al. 1985. J. Immunol. 134:1524
AB_2564615 (BioLegend Cat. No. 363510)
- Ig superfamily, a type I glycosylated integral transmembrane protein, 120-130 kD
- Adhesion, B-monocyte and B-T interactions
- CD45RO, CD75
- Cell Type
- B cells
- Biology Area
- Molecular Family
- CD Molecules, Siglec Molecules
- Antigen References
- Clark E. 1993. J. Immunol. 150:4715.
- Shan D, et al. 1995. J. Immunol. 154:4466.
- Gene ID
- 933 View all products for this Gene ID
- View information about CD22 on UniProt.org
- How many biotin molecules are per antibody structure?
- We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
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