- Ber-ACT35 (ACT35) (See other available formats)
- Regulatory Status
- Other Names
- ACT35 antigen, tumor necrosis factor receptor superfamily member 4 (TNFRSF4)
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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CD134, also known as OX40 and TNFRSF4, is a 50 kD type I transmembrane glycoprotein. It is a member of the TNF receptor family. OX40 is expressed on activated T lymphocytes including Th1, Th2, Th17, and Treg cells. The interaction of OX40 with OX40L results in B cell proliferation and antibody secretion, regulation of primary T cell expansion, and T cell survival. OX40 influences the size of the T cell memory pool and regulation of CD4+ T cell tolerance.Product Details
- Verified Reactivity
- Reported Reactivity
- Antibody Type
- Host Species
- HTLV 1-transformed HUT 102 cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications (for the relevant formats) include: Western blotting1, immunoprecipitation1, immunohistochemical staining2,3of paraffin embedded7 and frozen tissue sections, ELISA4, and functional assay5. The LEAF™ or Ultra-LEAF™ purified antibody is recommended for functional assays (contact our custom solutions team).
(PubMed link indicates BioLegend citation)
- Latza U, et al. 1994. Eur. J. Immunol. 24:677. (WB, IP)
- Durkop H, et al. 1995. Brit. J. Haematol. 91:927. (IHC)
- Durkop H, et al. 1997. Brit. J. Haematol. 98:863. (IHC)
- Willett B, et al. 2007. J. Virol. 81:9665. (ELISA)
- Li M and Zhang Y. et al. 2005. Cell. Mol. Immunol. 2:467. (FA)
- Gloviczki ML, et al. 2012. Clin. J. Am. Soc. Nephrol. 8:546. PubMed
- Domingos PL, et al. 2012. An. Bras. Dermatol. 87:851. (IHC)
AB_2571943 (BioLegend Cat. No. 350024)
- 50 kD, TNF receptor family
Activated T cells
- Receptor for OX40 ligand, co-stimulatory signal for T cell proliferation and survival.
- OX40L (CD252)
- Cell Type
- T cells, Tregs
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Costimulatory Molecules, Immunology
- Molecular Family
- CD Molecules, Immune Checkpoint Receptors
- Antigen References
1. Smith CA, et al. 1994. Cell. 76:959.
2. Chen AL, et al. 1999. Immunity. 11:689.
3. Croft M. 2010. Annu. Rev. Immunol. 28:57.
4. Withers DR, et al. 2009. J. Immunol. 183:5079.
5. Klinger M, et al. 2009. J. Immunol. 182:4581.
- Gene ID
- 7293 View all products for this Gene ID
- View information about CD134 on UniProt.org
- How many biotin molecules are per antibody structure?
- We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
FITC anti-human CD134 (OX40)
Purified anti-human CD134 (OX40)
PE anti-human CD134 (OX40)
APC anti-human CD134 (OX40)
PerCP/Cyanine5.5 anti-human CD134 (OX40)
PE/Cyanine7 anti-human CD134 (OX40)
Brilliant Violet 421™ anti-human CD134 (OX40)
Purified anti-human CD134 (OX40) (Maxpar® Ready)
Alexa Fluor® 647 anti-human CD134 (OX40)
PE/Dazzle™ 594 anti-human CD134 (OX40)
APC/Cyanine7 anti-human CD134 (OX40)
Biotin anti-human CD134 (OX40)
Brilliant Violet 510™ anti-human CD134 (OX40)
Brilliant Violet 605™ anti-human CD134 (OX40)
APC/Fire™ 750 anti-human CD134 (OX40)
Brilliant Violet 711™ anti-human CD134 (OX40)
TotalSeq™-A0158 anti-human CD134 (OX40)
TotalSeq™-C0158 anti-human CD134 (OX40)
TotalSeq™-B0158 anti-human CD134 (OX40)
TotalSeq™-D0158 anti-human CD134 (OX40)
PE/Cyanine5 anti-human CD134 (OX40)
PE/Fire™ 810 anti-human CD134 (OX40)