- DIH9 (See other available formats)
- Regulatory Status
- Other Names
- T1/ST2, ST2L, IL-1R1, T1, DER4, IL1R1
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
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IL-33Rα, also known as ST2 or IL-1RL1, is a member of the Toll/IL-1 receptor family. It binds IL-33 and is structurally similar to IL-1R1. Two forms of the protein exist - a soluble form known as ST2 and a membrane anchored form known as ST2L. The membrane form is expressed by Th2 cells and bone marrow derived mast cells, whereas the soluble form is expressed by serum-stimulated fibroblasts.
Blocking with anti-ST2 antibodies has been shown to alleviate experimental arthritis and airway inflammation. The IL-33-ST2 axis has been reported to be important across a range of diseases including asthma, allergies, and cardiac disease.
- Antibody Type
- Host Species
- IL-33Rα-hFcγ1 fusion protein.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography and conjugated with APC/Fire™ 750 under optimal conditions.
- 0.2 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
* APC/Fire™ 750 has a maximum excitation of 650 nm and a maximum emission of 787 nm.
- Excitation Laser
Red Laser (633 nm)
(PubMed link indicates BioLegend citation)
- Hashiguchi M, et al. 2014. Eur. J. Immunology. (FC) PubMed
- Product Citations
AB_2860704 (BioLegend Cat. No. 145325)
AB_2860705 (BioLegend Cat. No. 145326)
- 63 kD, IL-1 receptor family member, single pass type I membrane protein
Mast cells, Th2 cells, and fibroblasts
- Following interaction with IL-33, it recruits MyD88, Irak1, Irak4 and Traf6 followed by phosphorylation of the MAP/ERK pathway.
- Interacts with MyD88, Irak1, Irak4 and Traf6
- Cell Type
- Fibroblasts, Mast cells, Th2
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- Cytokine/Chemokine Receptors
- Antigen References
1. Yanagisawa K, et al. 1993. FEBS Lett. 318:83.
2. Schmitt E, et al. 1990. Cytokine 6:407.
3. Yanagisawa K, et al. 1992. FEBS Lett. 302:51.
4. Takagi T, et al. 1993. Biochim Biophys Acta. 1178:194.
- Gene ID
- 17082 View all products for this Gene ID
- View information about IL-33Ra on UniProt.org
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