- HMα1 (See other available formats)
- Other Names
- Very late antigen 1 (VLA1), integrin alpha 1 (ITGA1)
- Armenian Hamster IgG
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- Product Citations
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CD49a is a 1179 aa, type I transmembrane glycoprotein also known as α1 integrin, VLA-1 α chain, or integrin α1. It associates antibody v042010 with CD29 (β1 integrin) to form the VLA-1 complex, a collagen IV and alminin-1 receptor that is expressed on activated T cells, smooth muscle cells, endothelial cells, neuronal cells, fibroblasts, and mesenchymal cells. CD49a is an adhesion molecule and is involved in the regulation of leukocyte migration, T cell proliferation, and cytokine production.Product Details
- Antibody Type
- Host Species
- Armenian Hamster
- Mouse Neuroblastoma Cell Line C1300
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with APC/Fire™ 750 under optimal conditions.
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
* APC/Fire™ 750 has a maximum excitation of 650 nm and a maximum emission of 787 nm.
- Excitation Laser
Red Laser (633 nm)
- Application Notes
Additional reported applications (for the relevant format) include: inhibition of cell adhesion and cytokine production1,2.
(PubMed link indicates BioLegend citation)
- Miyake S, et al. 1994. Eur. J. Immunol. 24:2000. (FC, Block)
- Tanaka T, et al. 1995. Int. Immunol. 7:1183. (Block)
AB_2734203 (BioLegend Cat. No. 142609)
AB_2734204 (BioLegend Cat. No. 142610)
- 1179 aa, type I transmembrane glycoprotein
Endothelial cells, fibroblasts, activated T cells
- Leukocyte adhesion and homing; costimulation
- Collagens, laminin
- Cell Type
- Endothelial cells, Fibroblasts, Mesenchymal Stem Cells, T cells
- Biology Area
- Angiogenesis, Cell Adhesion, Cell Biology, Cell Motility/Cytoskeleton/Structure, Immunology, Innate Immunity, Signal Transduction, Stem Cells
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
1. Barczyk M, et al. 2010. Cell Tissue Res. 339:269.
- Gene ID
- 109700 View all products for this Gene ID
- View information about CD49a on UniProt.org
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