- L17F12 (See other available formats)
- Regulatory Status
- II T7
- Other Names
- Leu-1, Ly-1, T1, Tp67, Leu1
- Mouse IgG2a, κ
- Ave. Rating
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- Product Citations
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CD5, also known as Leu-1, Ly-1 and T1, is a 67 kD single chain type I glycoprotein that is a member of the scavenger receptor superfamily. CD5 is expressed on T cells, thymocytes, B cell subsets, chronic B lymphocytic leukemia (B-Cells), and peripheral blood dendritic cells. CD5 modulates T and B cell receptor signaling, thymocyte maturation, and T-B cell interactions. One of its ligands is CD72.Product Details
- Antibody Type
- Host Species
- Human T-acute lymphoblastic leukemia (ALL) cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography and conjugated with APC/Fire™ 750 under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
* APC/Fire™ 750 has a maximum excitation of 650 nm and a maximum emission of 787 nm.
- Excitation Laser
Red Laser (633 nm)
- Application Notes
Additional reported applications (for the relevant formats): immunoprecipitation1,3,4 and immmunohistochemical staining of frozen and formalin-fixed paraffin-embedded sections2,3,5.
(PubMed link indicates BioLegend citation)
- McAlister MS, et al. 1998. Protein Eng. 11:847. (IP)
- Butmarc JR, et al. 1998. Am. J. Clin. Pathol. 109:682. (IHC)
- Engleman EG, et al. 1981. Proc. Natl. Acad. Sci. USA 78:1791. (IHC, IP)
- Ledbetter JA, et al. 1981. J. Exp. Med. 153:310. (FC, IP)
- Warnke R and Levy R. 1980. J. Histochem. Cytochem. 28:771. (IHC)
- Product Citations
AB_2734405 (BioLegend Cat. No. 364027)
AB_2734406 (BioLegend Cat. No. 364028)
- Scavenger receptor superfamily, 67 kD
Thymocytes, T cells, and subsets of B and dendritic cells.
- Modulates TCR and BCR signaling, involved in thymocyte maturation and T-B cell interaction
- Cell Type
- B cells, Dendritic cells, T cells, Thymocytes
- Biology Area
- Immunology, Costimulatory Molecules
- Molecular Family
- CD Molecules
- Antigen References
1. Kipps T. 1989. Adv. Immunol. 47:117.
2. Resnick D, et al. 1994. Trends Biochem. Sci. 1:5.
3. Wood GS and Freudenthal PS. 1992. Am. J. Pathol. 141:789.
- Gene ID
- 921 View all products for this Gene ID
- View information about CD5 on UniProt.org
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