- A17082A (See other available formats)
- Other Names
- beta2-microglobulin b2-M, b2M
- Mouse IgG1, κ
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- Product Citations
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β2-microglobulin (β2M) is a 12 kD nonpolymorphic Ig like protein. It is a non-membrane-anchored glycoprotein and is noncovalently associated with 39-44 kD polymorphic heavy chains of MHC class I molecules to form HLA class I antigen complex. In association with HLA class I, β2M is expressed on all leukocytes, platelets, endothelial cells, and epithelial cells. β2M plays an essential role both in governing MHC class I molecules stability and in promoting antigen binding and presenting the antigen to CD3/TCR complex of CD8+ T cells.Product Details
- Antibody Type
- Host Species
- Recombinant human Beta2-microglobulin
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography and conjugated with APC/Fire™ 750 under optimal conditions. The solution is free of unconjugated APC/Fire™ 750 and unconjugated antibody.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
* APC/Fire™ 750 has a maximum excitation of 650 nm and a maximum emission of 787 nm.
- Application Notes
Clone A17082A partially cross-blocks anti-human β2-microglobulin clone 2M2 and does not block anti-human HLA-A,B,C clone W6/32 staining, based on in-house testing.
- 12 KD, Ig like structure
Leukocytes, platelets, endothelial cells, epithelial cells and other nucleated cells.
- Form MHC class I
- MHC class I heavy chain and other MHC I like molecules.
- Cell Type
- Antigen-presenting cells, Endothelial cells, Epithelial cells, Leukocytes, Platelets
- Biology Area
- Cancer Biomarkers, Immunology, Innate Immunity
- Molecular Family
- MHC Antigens
- Antigen References
- Engelhard VH. 1994. Curr. Opin. Immunol. 6:13.
- Williams DB, et al. 1989. J. Immunol. 142:2796.
- Danliczyk UG and TL. Delovitch. 1994. J. Immunol. 153:3533.
- Williams A, et al. 2002. Tissue Antigens. 59:3.
- Gene ID
- 567 View all products for this Gene ID
- View information about β2-microglobulin on UniProt.org
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