- 4D4/mTIGIT (See other available formats)
- Regulatory Status
- Other Names
- TIGIT, Vstm3, WUCAM, VSIG9
- Armenian Hamster IgG
- Ave. Rating
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- Product Citations
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T cell immunoreceptor with Ig and ITIM domains (TIGIT), also known as V-set and transmembrane domain-containing protein 3 (Vstm3), is a 26 kD, type I transmembrane protein and member of the CD28 family. TIGIT is expressed on activated T cells, follicular T helper, memory, and regulatory T cells as well as on NK cells. Its binding partners include CD155 (PVR) and CD112 (PVRL2). TIGIT is a negative regulator of NK and T cell activation. Engagement of TIGIT by dendritic cells results in their differentiation into a tolerogenic phenotype, with an increased secretion of IL-10 and a diminished production of IL-12. Mice deficient for TIGIT are more susceptible to autoimmune disease.Product Details
- Antibody Type
- Host Species
- Armenian Hamster
- Mouse TIGIT Tetramers
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- 0.2 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
Red Laser (633 nm)
- Application Notes
It was reported that this clone can block the interaction between mouse TIGIT and CD155.
(PubMed link indicates BioLegend citation)
- Joller N, et al. 2011. J. Immunol. 186:1338.
AB_2750514 (BioLegend Cat. No. 156105)
AB_2750515 (BioLegend Cat. No. 156106)
- Type I transmembrane protein, 26 kD, member of the CD28 family. Contains 1 Ig-like domain and 1 cytoplasmic ITIM motif.
Activated T cells, follicular T helper cells, NK, memory T cells, Tregs.
- Negative regulator of T cell activation and proliferation. Induction of tolerogenic dendritic cells.
- CD155 (PVR) and CD112 (PVRL2).
- Cell Type
- Dendritic cells, NK cells, T cells, Tregs
- Biology Area
- Immunology, Inhibitory Molecules
- Molecular Family
- Adhesion Molecules, Immune Checkpoint Receptors
- Antigen References
- Levin SD, et al. 2011. Eur. J. Immunol. 41:902.
- Yu X, et al. 2009. Nat. Immunol. 10:48.
- Stanietsky N, et al. 2009. Proc. Natl. Acad. Sci. USA 106:17858
- Gene ID
- 100043314 View all products for this Gene ID
- View information about TIGIT on UniProt.org
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