- S16009A (See other available formats)
- Regulatory Status
- Other Names
- Prf1, Pfp, Pfn, Pfn-1
- Rat IgG2a, κ
- Ave. Rating
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- Product Citations
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Perforin is a 70 kD cytolytic protein that is expressed in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Perforin is one of the major effector molecules used by cytotoxic T cells and NK cells to mediate targeted cell lysis.Product Details
- Antibody Type
- Host Species
- Mouse perforin transfected cells.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
Red Laser (633 nm)
- Application Notes
Clone S16009A reacts with perforin from both C57BL/6 and BALB/c strains.
- Product Citations
AB_2721462 (BioLegend Cat. No. 154303)
AB_2721463 (BioLegend Cat. No. 154304)
- 70 kD Protein that oligomerizes for pore formation.
CTL, NK (Cytoplasmic Granules)
- Target cell lysis
- Cell Type
- NK cells, T cells
- Biology Area
- Molecular Family
- Antigen References
- Podack ER, et al. 1988. Immunol. Rev. 103:203.
- Konjar S, et al. 2010. Immunology. 131:257.
- Trapani JA, et al. 2002. Nat. Rev. Immunol. 2:735.
- Osinska I, et al. 2014. Cent. Eur. J. Immnol. 39:109.
- Gene ID
- 18646 View all products for this Gene ID
- View information about Perforin on UniProt.org
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