Loading...

APC anti-mouse F4/80 Antibody

Pricing & Availability
Clone
BM8 (See other available formats)
Regulatory Status
RUO
Other Names
EMR1, Ly71
Isotype
Rat IgG2a, κ
Ave. Rating
Submit a Review
Product Citations
publications
BM8_APC_122007
Thioglycolate-elicited BALB/c mouse peritoneal macrophages stained with BM8 APC
  • BM8_APC_122007
    Thioglycolate-elicited BALB/c mouse peritoneal macrophages stained with BM8 APC
Compare all formats See APC spectral data
Cat # Size Price Quantity Check Availability Save
123115 25 µg £35
Check Availability


Need larger quantities of this item?
Request Bulk Quote
123116 100 µg £98
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

F4/80 is a 160 kD glycoprotein. It is characterized as a member of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family. F4/80, also known as EMR1 or Ly71, has been widely used as a murine macrophage marker, which is expressed on the majority of tissue macrophages including peritoneal macrophages, macrophages in lung, gut, thymus and red pulp of spleen (but not on the macrophages located in T cell areas of the spleen, lymph node and Peyer's patch), Kuffer cells, Langerhans cells, and bone marrow stromal cells. F4/80 has also been shown on a subset of dendritic cells. The biological ligand of F4/80 has not been identified, but it has been reported that F4/80 is required for induction of CD8+ T cells-mediated peripheral tolerance.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Murine macrophages
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The F4/80 antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections1,2 and formalin-fixed paraffin-embedded sections6,7, Western blotting, and spatial biology (IBEX)12,13.

Application References

(PubMed link indicates BioLegend citation)
  1. Schaller E, et al. 2002. Mol. Cell. Biol. 22:8035. (IHC)
  2. Stevceva L, et al. 2001. BMC Clin Pathol. 1:3. (IHC)
  3. Kobayashi M, et al.2008. J. Leukoc. Biol. 83:1354. PubMed
  4. Poeckel D, et al. 2009. J. Biol Chem. 284:21077. PubMed
  5. Glass AM, et al. 2013. J. Immunol. 190:4830. PubMed
  6. Koehm S, et al. 2007. J. Allergy Clin. Immunol. 120:570. (IHC)
  7. Rankin AL, et al. 2010. J. Immunol. 184:1526. (IHC)
  8. Sasi SP, et al. 2014. J Biol Chem. 289:14178. PubMed
  9. Thakus VS, et al. 2014. Toxicol Lett. 230:322. PubMed
  10. Watson NB, et al. 2015. J Immunol. 194:2796. PubMed
  11. Hirakawa H, et al. 2015. PLoS One. 10:119360. PubMed
  12. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  13. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Huang W, et al. 2015. J Allergy Clin Immunol. . PubMed
  2. Barrett N, et al. 2016. Cell Rep. 16: 1039-1054. PubMed
  3. Liu Y, et al. 2021. Cell Metabolism. 33(6):1221-1233.e11. PubMed
  4. Ying W, et al. 2019. Cell Metab. 29:457. PubMed
  5. Saha D et al. 2017. Cancer cell. 32(2):253-267 . PubMed
  6. Zhao Z, et al. 2021. Nat Commun. 12:4355. PubMed
  7. Marchelletta RR, et al. 2021. J Clin Invest. 131:. PubMed
  8. Nguyen T, et al. 2021. STAR Protoc. 2:101004. PubMed
  9. Grandjean CL, et al. 2021. Sci Adv. 7:. PubMed
  10. Deng R, et al. 2022. Adv Sci (Weinh). 9:e2103343. PubMed
  11. Yang D, et al. 2022. Cell. 185:1905. PubMed
  12. Zheng J, et al. 2022. Front Pharmacol. 13:866228. PubMed
  13. Furrer R, et al. 2021. Sci Adv. 7:eabi4852. PubMed
  14. Li Z, et al. 2022. Nat Commun. 13:1845. PubMed
  15. Platt DJ, et al. 2021. Cell Reports. 35(6):109113. PubMed
  16. Du J, et al. 2020. Developmental Cell. 55(6):737-753.e7. PubMed
  17. Gerwing M, et al. 2020. Mol Imaging Biol. 1.959027778. PubMed
  18. Bousset L, et al. 2020. PLoS Biol. 18:e3000948. PubMed
  19. Yu J, et al. 2020. Sci Rep. 10:21360. PubMed
  20. Sharma-Chawla N, et al. 2016. Infect Immun . . PubMed
  21. Emal D, et al. 2016. J Am Soc Nephrol. 10.1681/ASN.2016030255. PubMed
  22. Dale M, et al. 2016. J Immunol. 196: 4536 - 4543. PubMed
  23. Kawano H, et al. 2016. Int Immunol. 28: 489 - 501. PubMed
  24. Jaiswal M, et al. 2015. Sci Rep. 5: 15221. PubMed
  25. Bieren J, et al. 2015. J Immunol. 194:1154. PubMed
  26. Prantner D, et al. 2009. Infect Immun. 77:5334. PubMed
  27. Cullis J, et al. 2017. Cancer Immunol Res. 5:182. PubMed
  28. Kim SE, et al. 2019. Nutrients. 11. PubMed
  29. Chang T, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006485. PubMed
  30. Yan X, et al. 2022. Commun Biol. 5:320. PubMed
  31. Li Y, et al. 2022. Int J Biol Sci. 18:3697. PubMed
  32. He R, et al. 2021. J Immunol. 206:2353. PubMed
  33. Suresh R, et al. 2020. J Immunother Cancer. 8:. PubMed
  34. Symeonidou V, et al. 2021. Cell Rep. 37:109900. PubMed
  35. Zhang R, et al. 2021. Cell Mol Immunol. 18:1222. PubMed
  36. Kurosawa M, et al. 2021. Int J Mol Sci. 22:. PubMed
  37. He F, et al. 2021. J Exp Med. 218:. PubMed
  38. Stubelius A, et al. 2012. Immunobiology. 217:751. PubMed
  39. Sjöstrand M, et al. 2013. J Immunol. 191:3753. PubMed
  40. Li X, et al. 2015. Proc Natl Acad Sci U S A. 112:6080. PubMed
  41. Tan X, et al. 2016. PLoS One. 11: 0160985. PubMed
  42. Yilmaz B, et al. 2021. Cell Host Microbe. 29(4):650-663.e9. PubMed
  43. Dong L, et al. 2021. Cancer Cell. . PubMed
  44. Gonçalves NP, et al. 2017. J Neuroinflammation. 14:115. PubMed
  45. Yates C, et al. 2017. Stem Cell Res Ther. 10.1186/s13287-017-0644-9. PubMed
  46. Lancaster JN, et al. 2019. Nat Commun. 10:2220. PubMed
  47. Chou YJ, et al. 2020. Sci Rep. 10:8422. PubMed
  48. Lee H, et al. 2020. Cell Metabolism. 31(4):822-836. PubMed
  49. Jiang W, et al. 2021. Oncol Lett. 22:625. PubMed
  50. Liang S, et al. 2022. Acta Pharm Sin B. 12:2494. PubMed
  51. Sepe JJ, et al. 2022. JACC Basic Transl Sci. 7:915. PubMed
  52. Nam J, et al. 2021. Adv Sci (Weinh). 2002577:8. PubMed
  53. de Mingo Pulido , et al. 2021. Immunity. 54(6):1154-1167.e7. PubMed
  54. Zheng H, et al. 2021. Frontiers in Cell and Developmental Biology. 9:641527. PubMed
  55. Xu Y, et al. 2020. Mol Ther. 28:202. PubMed
  56. Mia MM, et al. 2020. PLoS Biol. 18:e3000941. PubMed
  57. Xing J, et al. 2016. Nat Immunol. 17:1373-1380. PubMed
  58. Zhu J, et al. 2016. Sci Rep. 6:27136. PubMed
  59. Sun P, et al. 2015. J Hepatol. . PubMed
  60. Shen H, et al. 2015. Infect Immun . 83: 2694 - 2704. PubMed
  61. Gritsina G, et al. 2015. Mol Cancer Ther. 14:1035. PubMed
  62. Wong E, et al. 2019. Cell Rep. 29:3047. PubMed
  63. Wu R, et al. 2019. J Cell Mol Med. 24:1684. PubMed
  64. Álvaro de Mingo Pulido et al. 2018. Cancer cell. 33(1):60-74 . PubMed
  65. Neumann AM et al. 2017. PloS one. 12(11):e0187330 . PubMed
  66. Han J, et al. 2022. FEBS J. 289:417. PubMed
  67. Zhao J, et al. 2022. J Nanobiotechnology. 20:62. PubMed
  68. Liang F, et al. 2021. Front Immunol. 12:658715. PubMed
  69. Rybalko V, et al. 2015. PLoS One. 10: 0145550. PubMed
  70. Ohtsuki T, et al. 2016. J Virol. 90: 300 - 307. PubMed
  71. Tajfirouz D, et al. 2017. Virology. 10.1016/j.virol.2017.02.022. PubMed
  72. Krivanek J, et al. 2020. Nat Commun. 3.802777778. PubMed
  73. Brestoff JR, et al. 2021. Cell Metab. 33:270. PubMed
  74. Evren E, et al. 2020. Immunity. 54(2):259-275.e7. PubMed
  75. Esmaili S, et al. 2021. Cell Systems. 12(5):432-445.e7. PubMed
  76. Jeong D, et al. 2021. eLife. 0.416666666666667. PubMed
  77. Molina-Sanchez P, et al. 2020. Gastroenterology. 2203:159. PubMed
  78. Qi F, et al. 2017. Molecular Immunology. 10.1016/j.molimm.2017.05.008. PubMed
  79. Stefan K, et al. 2017. PLoS One. . 10.1371/journal.pone.0188600. PubMed
  80. Sinha M, et al. 2018. Nat Commun. 9:936. PubMed
  81. Grohmann M et al. 2018. Cell. 175(5):1289-1306 . PubMed
  82. Kosack L, et al. 2017. Sci Rep. 7:11289. PubMed
  83. Christopher S Garris et al. 2018. Immunity. 49(6):1148-1161 . PubMed
  84. Duarte N, et al. 2018. Hepatol Commun. 0.833333333. PubMed
  85. Zhong J, et al. 2018. Sci Adv. 4:eaas9864. PubMed
  86. Sun Q, et al. 2022. Cell Death Dis. 13:724. PubMed
  87. He C, et al. 2021. Oncoimmunology. 1897295:10. PubMed
  88. Jiao H, et al. 2021. Cell. 184(11):2896-2910.e13. PubMed
  89. Shang Y, et al. 2016. Nat Immunol. 10.1038/ni.3486. PubMed
  90. Lasky C, et al. 2015. Infect Immun . 83: 2627 - 2635. PubMed
  91. Peng L, et al. 2020. Transl Lung Cancer Res. 0.892361111. PubMed
  92. Vannini N, et al. 2019. Cell Stem Cell. 24:405. PubMed
  93. Nguyen CM, et al. 2019. Diabetes. 68:1499. PubMed
  94. Dey A et al. 2019. The EMBO journal. 38(7) pii: e100293. PubMed
  95. Cao W, et al. 2017. Immunity. 47:1182. PubMed
  96. Wang Y, et al. 2022. Front Immunol. 13:767630. PubMed
  97. Hou H, et al. 2021. Front Cell Dev Biol. 9:737003. PubMed
  98. Kosaric N, et al. 2020. Mol Ther. 28:2007. PubMed
  99. Ling X, et al. 2021. ACS Nano. 15:765. PubMed
  100. Gordon RA, et al. 2020. PLoS One. 15:e0226396. PubMed
  101. Helmi N, et al. 2015. J Infect Dis. 211:1677. PubMed
  102. Tsoyi K, et al. 2015. J Leukoc Biol. 97:171. PubMed
  103. Ma Y, et al. 2015. Cardiovasc Res. 106:421. PubMed
  104. Ben-Shaanan T, et al. 2016. Nat Med. 10.1038/nm.4133. PubMed
  105. Karki R, et al. 2020. JCI Insight. 5:00. PubMed
  106. Chi Z, et al. 2020. Molecular Cell. 80(1):43-58.e7. PubMed
  107. Sun L, et al. 2020. J Immunol. 2177:204. PubMed
  108. Müller A, et al. 2020. J Clin Invest. 5765:130. PubMed
  109. Parada-Kusz M, et al. 2018. Dis Model Mech. 11:. PubMed
  110. Luan HH et al. 2019. Cell. 178(5):1231-1244 . PubMed
  111. Shimokawa C et al. 2017. Immunity. 46(5):863-874 . PubMed
  112. Giri J, et al. 2020. Cell Rep. 30:1923. PubMed
  113. Galvão I, et al. 2018. Front Immunol. 9:142. PubMed
  114. Alexander RK, et al. 2020. eLife. 9:e54090.. PubMed
  115. Prantner D, et al. 2011. Infect Immun. 79:3922. PubMed
  116. Jeong SJ, et al. 2021. Autophagy. 17:3740. PubMed
  117. Guo W, et al. 2022. J Immunother Cancer. 10:. PubMed
  118. Shin JE, et al. 2021. Heliyon. 7:e08433. PubMed
  119. Rao X, et al. 2022. Cell Death Dis. 13:891. PubMed
  120. Carozza JA, et al. 2020. Nat Cancer. 184:1. PubMed
  121. Agrawal V, et al. 2016. J Leukoc Biol. 100: 261 - 274. PubMed
  122. Amash A, et al. 2016. J Immunol. 196: 3331-3340. PubMed
  123. Gereke M, et al. 2012. J Vis Exp. 70: 4322. PubMed
  124. Sullivan B, et al. 2015. PLoS Pathog. 11:1004588. PubMed
  125. Oatley J, et al. 2009. Development. 136:1191. PubMed
  126. Frazier T, et al. 2018. Adipocyte. 0.41875. PubMed
  127. An W et al. 2019. British journal of pharmacology. 176(5):699-710 . PubMed
  128. Yu Y, et al. 2019. J Clin Invest. 129:546. PubMed
  129. Linde N, et al. 2018. Nat Commun. 9:21. PubMed
  130. Anstine L,et al. 2017. J Am Heart Assoc.. 10.1161/JAHA.117.007097. PubMed
  131. Zein HS, et al. 2022. Sci Rep. 12:4834. PubMed
  132. Luo W, et al. 2022. Front Immunol. 13:816761. PubMed
  133. Lv F, et al. 2022. iScience. 25:103639. PubMed
  134. Wu L, et al. 2022. Theranostics. 12:842. PubMed
  135. Stump CT, et al. 2021. Open Biol. 11:210245. PubMed
  136. Jiao Y, et al. 2021. Crit Care. 25:356. PubMed
  137. Gao H, et al. 2021. Cells. 10:. PubMed
  138. Glauser D, et al. 2013. J Virol. 87:10828. PubMed
  139. Bretscher P, et al. 2015. EMBO Mol Med. 7:593. PubMed
  140. Hara-Chikuma H 2016. Mol Cell Biol. 36: 1206-1218. PubMed
  141. Hu J, et al. 2020. Theranostics. 7.154166667. PubMed
  142. DeVito NC, et al. 2021. Cell Reports. 35(5):109071. PubMed
  143. Gozgit JM, et al. 2021. Cancer Cell. :. PubMed
  144. Chen F et al. 2018. Cell reports. 25(10):2775-2783 . PubMed
  145. Liao T, et al. 2017. Front Immunol. 8:1334. PubMed
  146. Deng M, et al. 2020. Nat Commun. 11:2193. PubMed
  147. Mao FY, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:395. PubMed
  148. Shi R, et al. 2022. Theranostics. 12:875. PubMed
  149. Du Y, et al. 2022. Nat Commun. 13:231. PubMed
  150. Tartey S, et al. 2021. Cancer Research. 81(9):2358-2372. PubMed
  151. Cheng Y, et al. 2020. PLoS Pathog. 16:e1008569. PubMed
  152. Wang W, et al. 2018. Oncogenesis. 7:97. PubMed
  153. Xie Z, et al. 2018. J Am Heart Assoc. 7:e007442. PubMed
  154. Pinho S, et al. 2022. Nat Cell Biol. 24:290. PubMed
  155. Lin S, et al. 2022. Nat Commun. 13:3301. PubMed
  156. Ye P, et al. 2022. Front Cardiovasc Med. 8:810477. PubMed
  157. Zhang Y, et al. 2021. J Immunol Res. 2021:5599439. PubMed
  158. Fairfax K, et al. 2013. J Immunol. 191:4202. PubMed
  159. Ericson J, et al. 2014. PLoS One. 9:108553. PubMed
  160. Toda G, et al. 2021. STAR Protoc. 2:100246. PubMed
  161. Guldner IH, et al. 2020. Cell. 183(5):1234-1248.e25. PubMed
  162. Engler AE, et al. 2020. Cell Reports. 33(13):108553. PubMed
  163. Fraccarollo D, et al. 2021. eLife. 0.416666666666667. PubMed
  164. Wang T, et al. 2018. Front Physiol. 9:209. PubMed
  165. Xiang W, et al. 2018. Nat Commun. 9:2574. PubMed
  166. Moon HG et al. 2018. Immunity. 49(2):275-287 . PubMed
  167. LaFleur MW, et al. 2019. Nat Commun. 10:1668. PubMed
  168. Hu J, et al. 2019. Mol Ther Nucleic Acids. 16:650. PubMed
  169. Matundan H, et al. 2019. J Virol. 93. PubMed
  170. Yu L, et al. 2019. Elife. 8:e46677. PubMed
  171. Ruiz de Azua I, et al. 2017. J Clin Invest. 127:4148. PubMed
  172. Li Y, et al. 2020. Cell Reports. 27(10):2809-2816.e3.. PubMed
  173. Pfefferlé M, et al. 2021. Front Immunol. 12:680855. PubMed
  174. Wara AK, et al. 2020. Cell Rep. 33:108550. PubMed
  175. Fu Z, et al. 2021. Cell Res. 31:631. PubMed
  176. Yang Y, et al. 2022. Elife. 11:. PubMed
  177. Frenis K, et al. 2021. Basic Res Cardiol. 31:116. PubMed
  178. Lei J, et al. 2021. Theranostics. 4251:11. PubMed
  179. Dewi IMW, et al. 2021. Cell Reports Medicine. 2(5):100289. PubMed
  180. Oguri Y, et al. 2020. Cell. 182(3):563-577.e20. PubMed
  181. Ni J, et al. 2020. Immunity. 52(6):1075-1087.e8. PubMed
  182. Madenspacher JH, et al. 2020. JCI Insight. 5:00. PubMed
  183. Kostadinova E, et al. 2016. Sci Rep. 6:30943. PubMed
  184. Tan X, et al. 2015. Sci Rep. 5: 15702. PubMed
  185. Kuwahara G, et al. 2014. PLoS One. 9:106987. PubMed
  186. Patankar Y, et al. 2013. Infect Immun . 81:2043. PubMed
  187. Kyburz A, et al. 2019. J Allergy Clin Immunol. 143:1496. PubMed
  188. Liu C et al. 2019. Immunity. 51(2):381-397 . PubMed
  189. Simula L et al. 2018. Cell reports. 25(11):3059-3073 . PubMed
  190. Tomay F, et al. 2019. J Transl Med. 17:237. PubMed
  191. Zhou J, et al. 2019. Nat Commun. 10:2427. PubMed
  192. Brown SM et al. 2017. Endocrinology. 158(10):3592-3604 . PubMed
  193. Nam GH, et al. 2018. Nat Commun. 9:2165. PubMed
  194. Zheng X, et al. 2018. J Clin Invest. 128:2104. PubMed
  195. Chung EJ, et al. 2022. Aging (Albany NY). 14:7692. PubMed
  196. Puigdelloses M, et al. 2021. J Immunother Cancer. 9:. PubMed
  197. Lang V, et al. 2021. Elife. 10:. PubMed
  198. Jaggi U, et al. 2021. PLoS Pathog. 17:e1009999. PubMed
  199. Rashid MH, et al. 2021. Oncol Rep. 45:1171. PubMed
  200. Tapia-Abellán A, et al. 2021. Sci Adv. 7:eabf4468. PubMed
  201. Henrich IC, et al. 2021. Cancer Res. 81:2171. PubMed
  202. Kim K, et al. 2014. Proc Natl Acad Sci U S A. 111:11774. PubMed
  203. Hu J, et al. 2015. J Hepatol. Available online 31 August 2015. PubMed
  204. Terrazas M 2014. Int J Parasit. 44 613 . PubMed
  205. Yang C, et al. 2016. Sci Rep. 6:34643. PubMed
  206. Jiang Q, et al. 2020. JCI Insight. 5:00. PubMed
  207. Kesavardhana S, et al. 2020. J Biol Chem. 295:8325. PubMed
  208. Cao Q, et al. 2019. Theranostics. 5.576388889. PubMed
  209. Ye ZH, et al. 2021. Transl Oncol. 14:101162. PubMed
  210. Ito T, et al. 2021. Nat Commun. 12:2232. PubMed
  211. Wuggenig P, et al. 2020. Commun Biol. 3:130. PubMed
  212. Xiao Y, et al. 2022. Nat Commun. 13:758. PubMed
  213. Ali S, et al. 2021. PLoS One. 16:e0246646. PubMed
  214. Yu W, et al. 2022. Nat Commun. 13:3544. PubMed
  215. Li Q, et al. 2022. Front Cardiovasc Med. 9:872102. PubMed
  216. Pandit M, et al. 2021. Eur J Immunol. 51:1461. PubMed
  217. Li D, et al. 2022. Emerg Microbes Infect. 11:2248. PubMed
  218. Ishikura S, et al. 2021. J Cell Biochem. . PubMed
  219. Wang G, et al. 2021. Cell Host Microbe. 29(5):777-791.e6. PubMed
  220. Desai P, et al. 2021. Cell. 184(5):1214-1231.e16. PubMed
  221. Chen Z, et al. 2016. Nat Commun. 7:11596. PubMed
  222. Deng W, et al. 2015. Clin Immunol. . PubMed
  223. Honda H, et al. 2014. J Leukoc Biol. 96:1087. PubMed
  224. Shaw O, et al. 2014. Rheumatology. 53:1901. PubMed
  225. Rosenbaum SR, et al. 2020. Cell Rep. 30:510. PubMed
  226. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  227. Petkevicius K, et al. 2019. Elife. 8:e47990. PubMed
  228. Cianciaruso C, et al. 2020. Cell Reports. 27(10):3062-3080.e11.. PubMed
  229. Engblom C, et al. 2017. Science. 358:6367. PubMed
  230. Zhao F et al. 2018. Immunity. 48(1):147-160 . PubMed
  231. Lima-Junior D, et al. 2017. J Immunol. 10.4049/jimmunol.1700258. PubMed
  232. Pascual-Pasto G, et al. 2022. J Immunother Cancer. 10:. PubMed
  233. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  234. Chen F, et al. 2022. Cell Rep. 38:110215. PubMed
  235. Wang S, et al. 2021. Commun Biol. 22:. PubMed
  236. Bent EH, et al. 2021. Nat Commun. 12:6218. PubMed
  237. Calle P, et al. 2021. Cells. 10:. PubMed
  238. Horsle B 2013. Development. 140:1517. PubMed
  239. Calderon B, et al. 2015. J Exp Med. 212: 1497-1512. PubMed
  240. Ding H, et al. 2016. Nat Commun. 7:11533. PubMed
  241. Gamradt P, et al. 2016. PLoS Pathog. 12:e1006032. PubMed
  242. Wang X, et al. 2016. J Immunol. 197(12):4750-4761. PubMed
  243. Zhang H, et al. 2017. Immunol Cell Biol. 10.1038/icb.2017.11. PubMed
  244. Tian Y, et al. 2020. JCI Insight. 5:00. PubMed
  245. Kerkhofs D, et al. 2020. Theranostics. 7.022222222. PubMed
  246. Toda G, et al. 2020. Molecular Cell. 79(1):43-53.e4. PubMed
  247. Karki R, et al. 2020. bioRxiv. . PubMed
  248. Di Genua C, et al. 2019. Haematologica. 104:2215. PubMed
  249. Hua X, et al. 2021. Front Immunol. 12:706027. PubMed
  250. Liu J, et al. 2021. Front Immunol. 12:733808. PubMed
  251. Feng L, et al. 2022. Signal Transduct Target Ther. 7:21. PubMed
  252. Zhang MS, et al. 2022. Nat Commun. 13:954. PubMed
  253. Pan Y, et al. 2021. Br J Pharmacol. 178:4907. PubMed
  254. Chen C, et al. 2020. Cell Rep. 2136:30. PubMed
  255. Li K, et al. 2020. J Cell Mol Med. 24:13115. PubMed
  256. Karki R, et al. 2021. Cell. 184:149. PubMed
  257. Caoa X, et al. 2017. Neurosci Lett. 10.1016/j.neulet.2017.02.045. PubMed
  258. Jeurissen M, et al. 2016. PLoS One. 11:e0167199. PubMed
  259. Montero-Barrera D, et al. 2015. BioMed Res Int. 2015 615865. PubMed
  260. Neimert-Andersson T, et al. 2011. Vaccine. 29:8965. PubMed
  261. Sun L, et al. 2009. FASEB J. 3.602777778. PubMed
  262. Esposito E, et al. 2019. Nat Commun. 4.101388889. PubMed
  263. Ji L et al. 2019. Immunity. 51(2):272-284 . PubMed
  264. Zhu K, et al. 2022. EMBO Rep. 23:e54499. PubMed
  265. Ding R, et al. 2022. J Neuroinflammation. 19:137. PubMed
  266. Liu R, et al. 2020. Eur J Vasc Endovasc Surg. 60:254. PubMed
  267. Zhang W, et al. 2021. Front Immunol. 12:768435. PubMed
  268. Panagi M, et al. 2020. Theranostics. 10:1910. PubMed
  269. Zhou H, et al. 2021. Cell Death Discov. 7:332. PubMed
  270. Gu H, et al. 2021. Elife. 10:. PubMed
  271. Nishio H, et al. 2020. Regen Ther. 14:262. PubMed
  272. Mirsoian A, et al. 2014. J Exp Med. 211:2373. PubMed
  273. Yin X, et al. 2015. J Immunol. 194:4029. PubMed
  274. Kuo P, et al. 2016. J Am Heart Assoc. 5: 002610. PubMed
  275. Santopaolo M, et al. 2021. Front Immunol. 609406:12. PubMed
  276. Wang Z et al. 2019. Cell reports. 26(5):1273-1285 . PubMed
  277. Nishino T, et al. 2018. Arterioscler Thromb Vasc Biol. 38:2460. PubMed
  278. Meng Michelle Xu et al. 2017. Immunity. 47(2):363-373 . PubMed
  279. Singh KS, et al. 2020. Nat Commun. 0.786805556. PubMed
  280. Chao Y, et al. 2020. Sci Adv. 6:eaaz4204. PubMed
  281. Chan JY, et al. 2019. Diabetologia. 62:993. PubMed
  282. Chen L, et al. 2021. Theranostics. 11:6668. PubMed
  283. Zhang A, et al. 2021. Theranostics. 11:3839. PubMed
  284. Adzika GK, et al. 2021. Front Cell Dev Biol. 9:719351. PubMed
  285. Liu SS, et al. 2021. Immunity. :. PubMed
  286. Freed-Pastor WA, et al. 2021. Cancer Cell. :. PubMed
  287. Cao H, et al. 2020. Front Pharmacol. 11:578943. PubMed
  288. Ngkelo A, et al. 2016. J Exp Med. 213: 1353 - 1374. PubMed
  289. Sockolosky J, et al. 2016. Proc Natl Acad Sci U S A. 113: 2646 - 2654. PubMed
  290. Wan X, Thomas J, Unanue E 2016. J Exp Med. 213: 967 - 978. PubMed
  291. Ishizuka M, et al. 2015. PLoS One. 10: 0137978. PubMed
  292. Pechous R, et al. 2015. MBio. 6:2302. PubMed
  293. Yin T, et al. 2015. J Immunol. 194:429. PubMed
  294. Klezovich-Bénard M, et al. 2012. PLoS One. 8:e1002481. PubMed
  295. Karpurapu M, et al. 2011. Blood. 118:5255. PubMed
  296. Yan K, et al. 2020. Cell Death Dis. 1.013888889. PubMed
  297. Eghbalzadeh K, et al. 2019. Front Immunol. 2.022916667. PubMed
  298. Ouadah Y, et al. 2019. Cell. 179:403. PubMed
  299. Ling X, et al. 2021. Biomaterials. 270:120690. PubMed
  300. Lau P, et al. 2022. Cell Mol Immunol. :. PubMed
  301. Zhou Y, et al. 2022. Theranostics. 12:5488. PubMed
  302. Sheng D, et al. 2022. J Immunother Cancer. 10:. PubMed
  303. Teng F, et al. 2021. Cell Rep. 37:110051. PubMed
  304. Adzika GK, et al. 2021. Front Cardiovasc Med. 8:719805. PubMed
  305. Wang X, et al. 2021. Theranostics. 11:209. PubMed
  306. Collins C, et al. 2014. Proc Natl Acad Sci U S A. 111:9899. PubMed
  307. Bramwell K, et al. 2015. J Immunol. 195: 1647 - 1656. PubMed
  308. Legrain S, et al. 2015. J Immunol. 195: 4171 - 4175. PubMed
  309. Schuijs M, et al. 2016. PLoS One. 11: 016188. PubMed
  310. Lerbs T, et al. 2020. JCI Insight. 5:00. PubMed
  311. Wang J, et al. 2020. Cell. 183(7):1867-1883.e26. PubMed
  312. Wu L, et al. 2020. Cancer Immunol Res. 710:8. PubMed
  313. Fu W, et al. 2020. J Immunol Res. 8820355:2020. PubMed
  314. Saul S, et al. 2019. J Leukoc Biol. N/A. PubMed
  315. Koupenova M, et al. 2019. iScience. 19:916. PubMed
  316. Yuan Y, et al. 2019. Clin Sci (Lond). 133:1759. PubMed
  317. Hong Y, et al. 2019. J Extracell Vesicles. 8:1670893. PubMed
  318. Boguslawski KM, et al. 2020. Sci Adv. 6:eaax7515. PubMed
  319. Kim M, et al. 2012. J Immunol. 188:4158. PubMed
  320. Gardner A, et al. 2022. J Immunother Cancer. 10:. PubMed
  321. Tang L, et al. 2022. Front Immunol. 12:770402. PubMed
  322. Caporarello N, et al. 2022. Nat Commun. 13:4170. PubMed
  323. Zhang B, et al. 2021. Front Neurol. 607370:12. PubMed
  324. Kapralov AA, et al. 2020. Nat Chem Biol. 278:16. PubMed
  325. Xiang W, et al. 2020. Signal Transduct Target Ther. 0.374305556. PubMed
  326. Badgujar DC, et al. 2020. PLoS Pathog. 16:e1009016. PubMed
  327. Steinmetz O, et al. 2016. J Infect Dis. 10.1093/infdis/jiv763. PubMed
  328. Malik M, et al. 2012. Proc Natl Acad Sci U S A. 109:6130. PubMed
  329. Kim SH, et al. 2020. Neoplasia. 1.3375. PubMed
  330. Maas SLN, et al. 2020. J Neuroinflammation. 17:120. PubMed
  331. Thomson CA, et al. 2018. J Immunol. 201:215. PubMed
  332. Sparber F et al. 2019. British journal of pharmacology. 176(11):1728-1744 . PubMed
  333. Lalor R, et al. 2019. Nutrients. 11. PubMed
  334. Fearon AE, et al. 2021. iScience. 24:103143. PubMed
  335. Chung EJ, et al. 2021. Int J Radiat Oncol Biol Phys. 110:526. PubMed
  336. Murray CW, et al. 2022. Nat Commun. 13:1090. PubMed
  337. Qu J, et al. 2021. Int J Biol Sci. 17:2756. PubMed
  338. Liu ZZ, et al. 2021. Front Immunol. 12:636861. PubMed
RRID
AB_893493 (BioLegend Cat. No. 123115)
AB_893481 (BioLegend Cat. No. 123116)

Antigen Details

Structure
EGF-TM7 family member, 160 kD glycoprotein
Distribution

Majority of tissue macrophages including peritoneal macrophages, macrophages in lung, gut, thymus and red pulp of spleen, Kuffer cells, Langerhans cells, bone marrow stromal cells, and a subset of dendritic cells

Function
Induction of immunological tolerance
Cell Type
Dendritic cells, Langerhans cells, Macrophages, Tregs
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
Antigen References

1. Austy JM and Gordon S. 1981. Eur. J. Immunol. 11:805.
2. Hume DA, et al. 1983. J. Exp. Med. 158:1522.
3. Ruedl C, et al. 1996. Eur. J. Immunol. 26:1801.
4. McKnight AJ, et al. 1996. J. Biol. Chem. 271:486.
5. Lin HH, et al. 2005. J. Exp. Med. 201:1615.

Gene ID
13733 View all products for this Gene ID
UniProt
View information about F4/80 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 10/25/2013

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

  • Brilliant Violet 605™ anti-mouse F4/80

  • Purified anti-mouse F4/80

  • Biotin anti-mouse F4/80

  • FITC anti-mouse F4/80

  • PE anti-mouse F4/80

  • PE/Cyanine5 anti-mouse F4/80

  • PE/Cyanine7 anti-mouse F4/80

  • APC anti-mouse F4/80

  • APC/Cyanine7 anti-mouse F4/80

  • Alexa Fluor® 488 anti-mouse F4/80

  • Alexa Fluor® 647 anti-mouse F4/80

  • Pacific Blue™ anti-mouse F4/80

  • PerCP anti-mouse F4/80

  • PerCP/Cyanine5.5 anti-mouse F4/80

  • Alexa Fluor® 700 anti-mouse F4/80

  • Brilliant Violet 421™ anti-mouse F4/80

  • Brilliant Violet 510™ anti-mouse F4/80

  • Alexa Fluor® 594 anti-mouse F4/80

  • Brilliant Violet 785™ anti-mouse F4/80

  • Purified anti-mouse F4/80 (Maxpar® Ready)

  • PE/Dazzle™ 594 anti-mouse F4/80

  • Brilliant Violet 650™ anti-mouse F4/80

  • Brilliant Violet 711™ anti-mouse F4/80

  • APC/Fire™ 750 anti-mouse F4/80

  • TotalSeq™-A0114 anti-mouse F4/80

  • TotalSeq™-B0114 anti-mouse F4/80

  • TotalSeq™-C0114 anti-mouse F4/80

  • Spark YG™ 570 anti-mouse F4/80

  • KIRAVIA Blue 520™ anti-mouse F4/80

  • Ultra-LEAF™ Purified anti-mouse F4/80

  • APC/Fire™ 810 anti-mouse F4/80

  • Spark NIR™ 685 anti-mouse F4/80
ProductsHere
Login / Register
Remember me
Forgot your password? Reset password?
Create an Account