- QA16A03 (See other available formats)
- Regulatory Status
- Other Names
- Chemokine (C-X3-C motif) receptor 1, Fractalkine receptor, GPR13, CCRL1, CMKBRL1, CMKDR1, V28
- Mouse IgG1, κ
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- Product Citations
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CX3CR1 is a 40 kD, G-protein coupled receptor, with seven transmembrane regions. CX3CR1 is expressed by resident and alternatively activated macrophages (M2), a subset of monocytes, dendritic cells (DCs), NK cells, a subset of memory T cells, and mast cells. CX3CR1 is involved in cell recruitment during inflammation and participates in cell adhesion and extravasation from blood vessels. Its ligand is CX3CL1, also known as fractalkine or neurotactin. CX3CR1 is also a coreceptor for HIV1 and variations in this gene leads to increased susceptibility to HIV. In the brain, it is expressed by glial cells, which interact with CX3CL1 expressed by neurons.Product Details
- Antibody Type
- Host Species
- Mouse CX3CR1-transfected cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
Red Laser (633 nm)
- Application Notes
This recombinant antibody clone is derived from clone SA011F11.
AB_2734223 (BioLegend Cat. No. 153707)
AB_2734224 (BioLegend Cat. No. 153708)
- G-protein coupled receptor, 7 transmembrane regions, 40 kD.
Resident and alternatively activated macrophages (M2), subset of monocytes, dendritic cells (DCs), natural killer cells (NK), subset of memory T cells, mast cells, glial cells, and astrocytes.
- Involved in cell recruitment during inflammation, participates in cell adhesion and extravasation from blood vessels, coreceptor for HIV1.
- CX3CL1 (fractalkine, neurotactin).
- Cell Type
- Astrocytes, Dendritic cells, Macrophages, Mast cells, Microglia, Monocytes, NK cells, T cells
- Biology Area
- Cell Biology, Immunology, Neuroinflammation, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- Cytokine/Chemokine Receptors, GPCR
- Antigen References
- Hamon P, et al. 2017. Blood.129:1296
- Afik R, et al. 2016. J Exp Med. 213:2315
- Mass E, et al. 2016. Science. 353 pii: aaf4238
- Safaiyan S, et al. 2016. Nat Neurosci. 19:995
- Peng J, et al. 2016. Nat Commun. 7:12029
- Gene ID
- 13051 View all products for this Gene ID
- View information about CX3CR1 on UniProt.org
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