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APC anti-mouse CD79a (Igα) Antibody

Pricing & Availability
Clone
F11-172 (See other available formats)
Regulatory Status
RUO
Other Names
Mb-1, Igα
Isotype
Armenian Hamster IgG
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Product Citations
publications
F11-172_APC_050409.jpg
C57BL/6 splenocytes were surface stained with CD45R/B220 (clone RA3-6B2) PE and intracellularly stained with CD79a (Igα) (clone F11-172) APC.
  • F11-172_APC_050409.jpg
    C57BL/6 splenocytes were surface stained with CD45R/B220 (clone RA3-6B2) PE and intracellularly stained with CD79a (Igα) (clone F11-172) APC.
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133105 25 µg £90
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133106 100 µg £223
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Description

Mouse CD79a (Ig α chain) is a 47 kD type I integral membrane protein, known as mb-1 or Ig α. It forms a heterodimer with CD79b (Ig β chain). The CD79a and CD79b heterodimers are associated with surface IgM to form the B-cell receptor (BCR) that is necessary for signal transduction via the BCR in mature B cells. CD79a may play a role in mediating the transport of IgM to the cell surface. Clone F11-172 antibody recognizes the 47 kD membrane glycoprotein present on B lymphocytes.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

ICFC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Kraus M, et al. 2001. J. Exp. Med. 194:455
Product Citations
  1. Rothstein B 2013. J Immunol. 191:670. PubMed
  2. Lino AC et al. 2018. Immunity. 49(1):120-133 . PubMed
RRID
AB_2075634 (BioLegend Cat. No. 133105)
AB_2260134 (BioLegend Cat. No. 133106)

Antigen Details

Structure
A 47 kD membrane glycoprotein which associates with CD79b to form part of B-cell receptor complex.
Distribution

CD79a is expressed on B cells at various differentiation stages, from pre-B cell to plasma cells. It is expressed probably before expression of cytoplasmic µu chain.

Function
Mediating the transport of IgM to the cell surface.
Ligand/Receptor
CD79a/CD79b heterodimers are associated with surface IgM to form B cell receptor complex (BCR) to recognize specific antigen.
Cell Type
B cells, Plasma cells
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Schamel W, et al. 2000. Immunity 13:5
2. Taddie JA, et al. 1994. J. Biol. Chem. 269:13529

Gene ID
12518 View all products for this Gene ID
UniProt
View information about CD79a on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 3    Revision Date: 05/06/2016

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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