APC anti-mouse CD41 Antibody

Pricing & Availability
Clone
MWReg30 (See other available formats)
Other Names
Fibrinogen receptor, gpIIb/IIIa, integrin alpha IIb, CD41a
Isotype
Rat IgG1, κ
Ave. Rating
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Product Citations
publications
MWREG30_APC_010412
Mouse platelets were stained with either anti-mouse CD41 (clone MWReg30) APC (filled histogram) or rat IgG1 APC isotype control (dashed histogram).
  • MWREG30_APC_010412
    Mouse platelets were stained with either anti-mouse CD41 (clone MWReg30) APC (filled histogram) or rat IgG1 APC isotype control (dashed histogram).
See APC spectral data
Cat # Size Price Quantity Avail. Save
133913 25 µg £58
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133914 100 µg £181
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Description

CD41, also known as integrin α2b and GPIIb, is a transmembrane glycoprotein that is expressed by platelets and megakaryocytes. It was reported that CD41 is also expressed on hematopoietic progenitors. CD41 associates with CD61 (integrin β3) to form complexes that interact with fibrinogen, fibronectin, von Willebrand factor, and thrombin. CD41 is required for platelet adhesion and aggregation. Defect of CD41 leads to disorders of coagulation.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse platelets
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: depletion of platelets and functional assay in vivo.4,7 The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for in vivo studies (Cat. No. 133939).

Application References

(PubMed link indicates BioLegend citation)
  1. Nieswandt B, et al. 1999. Blood 94:684.
  2. Teeling JL, et al. 2001. Blood 98:1095.
  3. Bertrand JY, et al. 2005. P. Natl. Acad. Sci. USA 102:134.
  4. Nocito A, et al. 2007. Hepatology 45:369. (Deplete)
  5. Sullivan BP, et al. 2010. Toxicol. Sci. 115:286. (Deplete) PubMed
  6. van der Heyde HC, et al. 2005. Blood 105:1956. (FA)
  7. Marjon KD, et al. 2009. J. Immunol. 182:1397. (Deplete)
Product Citations
  1. Kleppe M et al. 2018. Cancer cell. 33(1):29-43 . PubMed
  2. Chen X et al. 2017. Cell stem cell. 21(6):747-760 . PubMed
  3. Sung PS, et al. 2019. Nat Commun. 10:2402. PubMed
  4. Radulovic V, et al. 2020. Cell Reports. 27(10):2826-2836.e5.. PubMed
  5. Kobayashi H, et al. 2020. Cell Reports. 28(1):145-158.e9.. PubMed
  6. Da Q, et al. 2018. Microcirculation. 25:e12457. PubMed
  7. Pagan JD, et al. 2018. Cell. 172:564. PubMed
  8. Han P, et al. 2020. Sci Adv. 6:eaaz1580. PubMed
  9. Siddique SM, et al. 2019. Sci Rep. 9:13977. PubMed
  10. Chen W, et al. 2019. Arterioscler Thromb Vasc Biol. 39:2028. PubMed
  11. Kniewallner KM, et al. 2020. Front Neurosci. 14:129. PubMed
  12. Li H, et al. 2020. J Cell Mol Med. 24:3504. PubMed
  13. Wuescher LM, et al. 2019. Res Pract Thromb Haemost. 3:704. PubMed
  14. de Laval B, et al. 2020. Cell Stem Cell. 26(5):657-674. PubMed
  15. Fukushima T, et al. 2019. Cell Rep. 29:4144. PubMed
  16. McCabe A, et al. 2020. STAR Protocols. 33(7):2294-305. PubMed
  17. Kobayashi H, et al. 2020. STAR Protoc. 1:100078. PubMed
  18. Cordeiro O, et al. 2016. PLoS One. 11: 0151848. PubMed
  19. Wang W, et al. 2016. Circ Cardiovasc Genet. 9: 213 - 222. PubMed
  20. Zhang Q, et al. 2016. Sci Transl Med. 8: 349ra101. PubMed
  21. Upadhaya S, et al. 2020. Cell Stem Cell. 27(2):336-345.e4. PubMed
  22. Parker KR, et al. 2020. Cell. 183(1):126-142.e17. PubMed
RRID
AB_11126751 (BioLegend Cat. No. 133913)
AB_11125581 (BioLegend Cat. No. 133914)

Antigen Details

Structure
A transmembrane glycoprotein that is expressed by platelets and megakaryocytes
Distribution

Platelets, megakaryocytes, and hematopoietic progenitors

Function
Associate with CD61 (integrin β3) to form a complex which plays a major role in platelet adhesion and aggregation
Ligand/Receptor
Fibrinogen, fibronectin, von Willebrand factor, thrombin
Cell Type
Hematopoietic stem and progenitors, Megakaryocytes, Platelets
Biology Area
Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Bakewell SJ, et al. 2003. P. Natl. Acad. Sci. USA 100:14205.
2. Phillips DR, et al. 1991. Cell. 65:359.

Gene ID
16399 View all products for this Gene ID
UniProt
View information about CD41 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 03/19/2013

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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