APC anti-human Notch 2 Antibody

Pricing & Availability
Clone
MHN2-25 (See other available formats)
Regulatory Status
RUO
Other Names
Neurogenic locus notch homolog protein 2, hN2, fN2
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
MHN2-25_APC_101310
Human Notch-2 transfected CHO cells stained with Notch-2 (clone MHN2-25) APC (filled histogram) or rat IgG2a APC isotype control (open histogram)
  • MHN2-25_APC_101310
    Human Notch-2 transfected CHO cells stained with Notch-2 (clone MHN2-25) APC (filled histogram) or rat IgG2a APC isotype control (open histogram)
See APC spectral data
Cat # Size Price Quantity Check Availability Save
348305 25 tests £92.00
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348306 100 tests £202.00
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Description

The Notch receptors are a type I transmembrane protein family that share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. They are highly conserved from invertebrates to mammals. Notch 1 and Notch 2 exhibit the highest structural similarity among the four mammalian Notch receptors (Notch1-4).  Notch1 and Notch 2 are reported to be functionally redundant.  Notch 2 is expressed by Pre-B cells, double negative and CD8 single positive thymocytes, brain, lung cells. Notch 2 functions as a receptor for Jagged and Delta ligands, and may play a role in vascular, renal and hepatic development.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human, African Green
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human Notch 2-human IgG1 Fc fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Haraguchi K, et al. 2009. J. Immunol. 182:6168.
RRID
AB_10662748 (BioLegend Cat. No. 348305)
AB_10662412 (BioLegend Cat. No. 348306)

Antigen Details

Distribution
Double negative and CD8 single positive thymocytes, pre-B cells, brain, lung
Ligand/Receptor
Jag 1, Jag 2; Delta 1, Delta 4
Cell Type
Thymocytes, B cells, Neural Stem Cells
Biology Area
Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers, Stem Cells
Antigen References

1. Haraguchi K, et al. 2009. J. Immunol. 182:6168.
2. O’Neill CF, et al.2007. Am. J. Path. 171:1023.
3. Bertrand FE, et al. 2000. Leukemia 14:2095.

Gene ID
4853 View all products for this Gene ID
UniProt
View information about Notch 2 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11/30/2012

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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