APC anti-human CD369 (Dectin-1/CLEC7A) Antibody

Pricing & Availability
15E2 (See other available formats)
Regulatory Status
HCDM listed
Other Names
CLECSF12, beta-glucan receptor (BGR, betaGR), CD369
Mouse IgG2a, κ
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Product Citations
Human peripheral blood monocytes were stained with anti-human CD369 (Dectin-1/CLEC7A, clone 15E2) APC (filled histogram) or mouse IgG2a, κ APC isotype control (open histogram).
  • 15E2_APC_CD369_Antibody_012419
    Human peripheral blood monocytes were stained with anti-human CD369 (Dectin-1/CLEC7A, clone 15E2) APC (filled histogram) or mouse IgG2a, κ APC isotype control (open histogram).
Compare all formats See APC spectral data
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355405 25 tests £111
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355406 100 tests £232
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CD369 (Dectin-1), also known as CLEC7A and beta-glucan receptor (BGR), is a 33 kD type II transmembrane C-type lectin. It consists of a C-terminal stalk with a carbohydrate recognition domain (CRD) in the extracellular domain, a transmembrane segment, and a short N-terminal ITAM containing a cytoplasmic tail. CLEC7A is predominantly expressed on dendritic cells. Subsequent work has shown expression on B cells, monocytes, eosinophils, mast cells, macrophages, endothelial cells, and low expression on some subsets of T cells. CLEC7A lacks residues involved in calcium ligation that mediates carbohydrate-binding by classical C-type lectins. CLEC7A functions as a receptor to mediate innate immunity to fungal pathogens by selectively binding beta-glucan polymers, a major component of yeast and mycobacterial cell walls. 

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Antibody Type
Host Species
Ectodomain with C-term hFc fusion, RIBLS.
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Application Notes

The epitope of clone 15E2 is LWEDGSTFSSN. Clone 15E2 can recognize the epitope in the presence of Curdlan and Laminarin (CLEC7A ligands). Additional reported applications (for the relevant formats) include: immunohistochemical staining.1

Application References

(PubMed link indicates BioLegend citation)
  1. Ni L, et al. 2010. J. Immunol. 185:3504. (IHC)
AB_2800956 (BioLegend Cat. No. 355405)
AB_2800957 (BioLegend Cat. No. 355406)

Antigen Details

Type II transmemberane C-type lectin, one carbohydrate recognition domain, ITAM containing cytoplasmic tail

B cells, low level of some subsets of T cells, monocytes, dendritic cells, macrophages and endothelial cells

Mediates innate immunity to fungal pathogens
TLR2, CD37
Cell Type
B cells, Dendritic cells, Endothelial cells, Macrophages, Monocytes, T cells
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
CD Molecules
Antigen References

1. Goodridge HS, et al. 2011. Nature 472:471.
2. Saijo S, et al. 2007. Nat. Immunol. 8:39.
3. Brown GD. 2006. Nat. Rev. Immunol. 6:33.
4. Willment JA, et al. 2001. J. Biol. Chem. 276:43818.
5. Yokota K, et al. 2001. Gene 272:51.

Gene ID
64581 View all products for this Gene ID
View information about CD369 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 01/24/2019

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

  • Purified anti-human CD369 (Dectin-1/CLEC7A)

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  • APC anti-human CD369 (Dectin-1/CLEC7A)

  • PerCP/Cyanine5.5 anti-human CD369 (Dectin-1/CLEC7A)


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