APC anti-human CD261 (DR4, TRAIL-R1) Antibody

Pricing & Availability
DJR1 (See other available formats)
Regulatory Status
HCDM listed
Other Names
TRAIL-R1, Apo-2, CD261, TNFRSF10A
Mouse IgG1, κ
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Product Citations
Human DR4 transfected cells stained with DJR1 APC
  • DJR1_APC_021810
    Human DR4 transfected cells stained with DJR1 APC
See APC spectral data
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307207 25 tests £86.00
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307208 100 tests £192.00
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DR4 is 56 kD member 10A of the TNFR superfamily (TNFRSF10A), also known as TRAIL-R1, Apo-2, and CD261. It is expressed at low levels by activated T cells and some tumors. After TRAIL engagement, DR4 (TRAIL-R1), through activation of NF-κB, induces apoptosis in the TRAIL ligated cell.

Product Details
Technical Data Sheet (pdf)

Product Details

Human, African Green, Cynomolgus
Antibody Type
Host Species
Extracellular domain of DR4-human IgG1 Fc fusion protein
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: The DJR1 antibody is useful for immunofluorescent staining and flow cytometric analysis of DR4/TRAIL-R1 receptor expression. For most successful immunofluorescent staining results, it may be important to maximize signal over background by using a relatively bright fluorochrome-antibody conjugate (Cat. No. 307206) or by using a high sensitivity, three-layer staining technique (e.g., including a biotinylated antibody or biotinylated anti-mouse IgG second step (Cat. No. 405303), followed by SAv-PE (Cat. No. 405204)).

Application References

(PubMed link indicates BioLegend citation)
  1. Uno K, et al. 2003. Blood 101:3658.
  2. Sato K, et al. 2005. J. Immunol. 174:4025.
  3. Lundqvist A, et al. 2006. Cancer Res. 66:7317. PubMed
  4. Chen KF, et al. 2011. J Pharmacol Exp Ther. 337:155. PubMed
  5. Sonnemann J, et al. 2012. Cancer Biol Ther. 13:417. PubMed
  6. Chandrasekaran S, et al. 2014. PLoS One. 9:111487. PubMed
Product Citations
  1. Zhu ZC, et al. 2019. Cell Death Dis. 10:118. PubMed
  2. Roybal KT et al. 2016. Cell. 167(2):419-432 . PubMed
  3. Brin E, et al. 2018. Oncotarget. 9:36914. PubMed
  4. Phalke SP, et al. 2019. PLoS One. 14:e0218827. PubMed
  5. Malin D, et al. 2011. Clin Cancer Res. 4.184027778. PubMed
  6. Choi Y, et al. 2015. Gut. 64: 1303-1313. PubMed
  7. Burger J, et al. 2016. Nat Commun. 7:11589. PubMed
  8. Cordeau M, et al. 2016. PLoS One. 11:e0164401. PubMed
  9. Liu H, et al. 2020. J Crohns Colitis. 1619:14. PubMed
  10. Volpin V, et al. 2020. Cancer Immunol Res. 8:1163. PubMed
AB_2256112 (BioLegend Cat. No. 307207)
AB_2204667 (BioLegend Cat. No. 307208)

Antigen Details

TNFR superfamily, 56 kD

Activated T cells, tumor cells

Induces apoptosis
Cell Type
T cells
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References

1. Macfarlane M. 2003. Toxicol. Lett. 139:89.
2. Baetu T, et al. 2002. Cytokine Growth Factor Rev. 13:199.
3. Degli-Esposti M. 1999. J. Leukoc. Biol. 65:535.

Gene ID
8797 View all products for this Gene ID
View information about CD261 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11/30/2012

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.


*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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