- W16216D (See other available formats)
- Regulatory Status
- Other Names
- Poliovirus receptor-related immunoglobulin domain containing protein, PVRIG, C7orf15, CD112 receptor
- Rat IgG2a, κ
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- Product Citations
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CD112R gene encodes a single transmembrane protein consisting of a single extracellular IgV domain. Its long intracellular domain contains two tyrosine residues, one of which is within an ITIM-like motif. CD112R was initially named PVRIG for the homology observed between its second exon and the variable immunoglobulin domain of the polio virus receptor (PVR/CD155) and polio virus receptor-like (PVRL) genes. CD112R is a cell surface receptor for CD112/Nectin-2, it compete against CD226 in binding to CD112. Following interaction with CD112, CD112R inhibits T-cell proliferation and the disruption of interaction between CD112R and CD112 enhances T cell response. Published studies suggest that CD112R is a novel co-inhibitory receptor, or a checkpoint molecule, that suppressed TCR medicated signal.Product Details
- Antibody Type
- Host Species
- Human CD112R transfectants
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
Red Laser (633 nm)
AB_2876586 (BioLegend Cat. No. 301505)
AB_2876586 (BioLegend Cat. No. 301506)
- IgV domain; ITIM motif
T cells, NK cells
- Cell surface receptor for CD112, negative regulator of T cell response
- CD112 (Nectin-2)
- Cell Type
- Leukocytes, Lymphocytes, NK cells, T cells
- Biology Area
- Adaptive Immunity, Immuno-Oncology, Immunology, Inhibitory Molecules
- Molecular Family
- Immune Checkpoint Receptors
- Antigen References
- Xu F, et al. 2017. Cancer Immunol. Immunother. 66:1367-1375.
- Zhu Y, et al. 2016. J. Exp. Med. 213(2):167-76.
- Gene ID
- 79037 View all products for this Gene ID
- View information about CD112R on UniProt.org
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