Anti-TYRP1 (MEL-5) Antibody (Previously Covance catalog# SIG-38150)

Pricing & Availability
Ta99 (See other available formats)
Regulatory Status
Other Names
CAS2, CATB, GP75, OCA3, TRP, 5,6-dihydroxyindole-2-carboxylic acid oxidase, TRP1, TRP-1, catalase B, DHICA oxidase, glycoprotein 75, melanoma antigen gp75
Signet Catalog# 8150-01
Covance Catalog# SIG-38150
Mouse IgG2a
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Product Citations
Staining of MEL-5 (Ta99), on frozen human melanoma tissue.
  • Ta99_Purified_TYRP1_Antibody_IHC_032615
    Staining of MEL-5 (Ta99), on frozen human melanoma tissue.
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917801 1 mL £228.00
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Tyrosinase-related protein 1, also known as TYRP1 or MEL-5, is an enzyme found in melanocytes and is involved in the synthesis of melanin. TYRP1 stabilizes tyrosinase and modulates its catalytic activity. It is also involved in the maintenance of melanosome structures, as well as the proliferation and cell death of melanocytes.

Product Details
Technical Data Sheet (pdf)

Product Details

Antibody Type
Host Species
Ta99 was developed using a SK-MEL-23 Melanoma cell line.
Phosphate-buffered solution with BSA + 0.1% NaN3.
The antibody was purified by affinity chromatography.
Storage & Handling
Store between 2°C and 8°C.


Recommended Usage

Each lot of this antibody is quality control tested by immunohistochemical staining.

The optimal working dilution should be determined for each specific assay condition.
IHC: ≥1:20 (concentrated format) with Biotin based detection systems such as USA Ultra Streptavidin Detection (Cat. No. 929501).

Tissue Sections: The preferred specimens for this antibody are frozen tissue sections and/or cytocentrifuge preparations fixed 10 minutes in 4°C acetone.
Pretreatment: Not required.
Incubation: 60 minutes at room temperature

Application Notes

This antibody is effective in immunohistochemistry (IHC).

Positive tissue (human): Melanoma, normal skin

The BioLegend Mel 5 (Ta99) monoclonal antibody recognizes gp75, an abundant intracellular glycoprotein that is expressed in the melanosomes of human melanocytes and melanomas.

Application References

(PubMed link indicates BioLegend citation)
  1. Gross EA, et al. 1999. Archives Dermatol. 135:15.
  2. Bhawan, J, Cao SL. 1999. Am. J. Dermatopathol. 21:225.
  3. Kemp EH, et al. 1998. Br J Dermatol. 139:798.
  4. Burkhalter A, White WL. 1997. Am J Dermapathol. 19:303.
  5. Andersen WK, et al. 1997. J Am Acad Dermatol. 36:444.
  6. Bhawan J. 1997. Melanoma Res. 7:43.
  7. Zhao H, et al. 1996. J Invest Dermatol. 106:744.
  8. Cui J, et al. 1995. Pigment Cell Res. 8:53.
  9. Vijayasaradhi S, Houghton AN. 1991. Int J Cancer. 47:298.
  10. Thomson TM, et al. 1988. J Invest Dermatol. 90:459.
Product Citations
  1. Jackson E, et al. 2019. Int J Mol Sci. 5.099305556. PubMed
  2. Zurina IM, et al. 2020. Front Bioeng Biotechnol. 0.708333333. PubMed
  3. Ruhland MK, et al. 2020. Cancer Cell. 37(6):786-799.e5. PubMed
AB_2565201 (BioLegend Cat. No. 917801)

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For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.


*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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