Anti-CD271 (p75NTR) Antibody (Previously Covance catalog# PRB-602C)

Pricing & Availability
Clone
Poly18397 (See other available formats)
Other Names
Tumor Necrosis Factor Receptor Superfamily Member 16, P75 Icd, Ngf Receptor, Tnfr Superfamily, Member 16, Low Affinity Neurotrophin Receptor P75Ntr
Previously
Covance Catalog# PRB-602C
Isotype
Rabbit Polyclonal IgG
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Product Citations
publications
Cat # Size Price Quantity Avail. Save
839701 200 µl £204
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Description

p75 plays a pivotal role in the regulation of life and death decisions within developing neurons.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human, Mouse, Rat
Antibody Type
Polyclonal
Host Species
Rabbit
Immunogen
This polyclonal antibody was raised against residues 274-425 of rat p75NTR. This sequence comprises the C-terminal intracellular domain.
Preparation
Serum
Concentration
Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
Storage & Handling
Store at -20°C. It is suggested that the total volume be divided into useable aliquots upon initial thaw.
Application

WB, IHC, IP, IF

Recommended Usage

Each lot of this antibody is quality control tested by Immunohistochemical staining.

The optimal working dilution should be determined for each specific assay condition.
WB: 1:2,000*
IF: 1:2,000
IHC: 1:500
IP: 1:150

Application Notes

This antibody is effective in immunoblotting, immunohistochemistry, immunoprecipitation and immunofluorescence.

*Predicted MW = 75 kD


This product may contain other non-IgG subtypes.

Application References

(PubMed link indicates BioLegend citation)
  1. Kim JY, Sun Q, Oglesbee M, Yoon SO. The role of ErbB2 signaling in the onset of terminal differentiation of oligodendrocytes in vivo. J. Neurosci. 23(13):5561-5571, 2003. (IHC)
  2. Bhakar AL, Roux PP, Lachance C, Kryl D, Zeindler C, Barker PA. The p75 neurotrophin receptor (p75NTR) alters tumor necrosis factor-mediated NF-kappaB activity under physiological conditions, but direct p75NTR-mediated NF-kappaB activation requires cell stress. J. Biol. Chem. 274(30):21443-21449, 1999.
  3. Roux PP, Colicos MA, Barker PA, Kennedy TE. p75 neurotrophin receptor expression is induced in apoptotic neurons after seizure. J. Neurosci. 19(16):6887-6896, 1999.
  4. Majdan M, Lachance C, Gloster A, Aloyz R, Zeindler C, Bamji S, Bhakar A, Belliveau D, Fawcett J, Miller FD, Barker PA. Transgenic mice expressing the intracellular domain of the p75 neurotrophin receptor undergo neuronal apoptosis. J. Neurosci. 17(18):6988-6998, 1997.
  5. Shen W, et al. 2014. PLoS One.9:104759. (WB) PubMed
  6. Butowt R, et al. 2009. J Neurosci. 34:10715. (IP) PubMed
  7. Fukumoto S, et al. 2004. J Cell Sci. 167:973. (IHC) PubMed
  8. Jaaro H, et al. 2005. Mol Cell Proteomics. 4:328. (IF) PubMed
Product Citations
  1. Jaaro H, Fainzilber Z 2005. Mol Cell Proteomics. 4:328-333. PubMed
  2. Fukumoto S, et al. 2004. J Cell Biol. 167:973-983. PubMed
  3. Bartheld R 2009. J Neurosci. 29:10715-10729. PubMed
  4. Shen W, et al. 2014. PLoS One. 9:e104759. PubMed
  5. Delbary-Gossart S, et al. 2016. Brain. 139: 1762 - 1782. PubMed
Publication Library
RRID
AB_2565441 (BioLegend Cat. No. 839701)

Antigen Details

Cell Type
Mesenchymal Stem Cells
Biology Area
Cell Biology, Neuroscience, Stem Cells, Synaptic Biology
Molecular Family
Postsynaptic proteins
Gene ID
4804 View all products for this Gene ID
UniProt
View information about CD271 on UniProt.org

Related FAQs

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Go To Top Version: 2    Revision Date: 02/09/2017

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*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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