Alexa Fluor® 647 anti-mouse CD218a (IL-18Rα) Antibody

Pricing & Availability
BG/IL18RA (See other available formats)
Regulatory Status
Other Names
IL-1 Rrp, CDw218a, IL-18 receptor a
Rat IgG1
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Product Citations
C57BL/6 splenocytes stained with CD3 (145-2C11) PE and BG/IL18RA Alexa Fluor® 647
  • BGslashIL18RA_A647_042909.jpg
    C57BL/6 splenocytes stained with CD3 (145-2C11) PE and BG/IL18RA Alexa Fluor® 647
See Alexa Fluor® 647 spectral data
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132903 25 tests £103.00
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This product is scheduled for discontinuation. Please use the availability checker to determine current availability. Cat. Nos. 157907 and 157908 are available as alternatives.

The IL-18 receptor (IL-18R) complex is composed of two known chains, IL-18 receptor α (IL-18Rα) and IL-18 receptor β (IL-18Rβ). IL-18Rα (IL-1R5) is an IL-1 receptor super family member. It was originally described as IL-1 receptor-related protein (IL-1Rrp) because of its homology with the IL-1/Toll receptor family. IL-18Rα is the extracellular binding domain of the IL-18 receptor complex. It is expressed on the majority of peripheral CD4+ T cells, Th1 cells, and reciprocally repressed during Th2 development. The expression of IL-18Rα is induced by an IL-12/Stat4 pathway and inhibited by IL-4/Stat6 pathway. Binding of IL-18Rα together with IL-18β to proinflammatory cytokine IL-18 plays an important role in innate and autoimmune responses.

Product Details
Technical Data Sheet (pdf)

Product Details

Antibody Type
Host Species
Mouse NS0-derived rmIL-18Rα extracellular domain
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633nm / 635nm.

Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.

View full statement regarding label licenses
Excitation Laser
Red Laser (633 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Yu Q, et al. 2008. J. Immunol. 181:3346
  2. Pham D, et al. 2012. J. Immunol. 189:832. PubMed
  3. Tyznik AJ, et al. 2014. J. Immunol. 192:3676. PubMed
Product Citations
  1. Oliveira AC et al. 2017. eLife. 6 pii: e30883. PubMed
  2. Guichard V, et al. 2017. Elife. 6:e27215. PubMed
  3. Pham D, et al. 2012. J Immunol. 189:832. PubMed
  4. Tyznik A, et al. 2014. J Immunol. 192:3676. PubMed
  5. Christian LS, et al. 2021. Cell Reports. 35(6):109118. PubMed
  6. McFarland AP, et al. 2021. Immunity. 54(6):1320-1337.e4. PubMed
  7. Zeis P, et al. 2020. Immunity. 53:775. PubMed
AB_2123952 (BioLegend Cat. No. 132903)

Antigen Details

An IL-1 receptor super family member

Expressed on T cells, NK cell subset, neutrophils, IL-12 stimulated tonsillar B cells, and intestinal epithelial cells (IEC).

Bind to pro inflammatory cytokine IL-18 and play an important role in innate and autoimmune responses.
Cell Type
Neutrophils, NK cells, T cells
Biology Area
Immunology, Innate Immunity
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References

1. Parnet P, et al. 1996. J. Biol. Chem. 271 :3967
2. Thomassen E, et al. 1998. J. Interferon Cytokine Res. 18:1077
3. Debets R, et al. 2000. J. Immunol. 165:4950
4. Smeltz RB, et al. 2001. J. Exp. Med. 194:143

Gene ID
16182 View all products for this Gene ID
View information about CD218a on

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Go To Top Version: 2    Revision Date: 06/27/2014

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.


*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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