- S16021I (See other available formats)
- Other Names
- SLE1, TIL3, SLEB1, MELIOS, CD285
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
|Cat #||Size||Price||Quantity Avail.||Save|
CD285, also known as TLR5, is a 98 kD pattern recognition receptor that binds to bacterial flagellin. It is expressed on dendritic cells, classical monocytes and mucosal epithelial cells and is involved in activation of TLR5 induced NF-κB mediated activation of inflammatory-related target genes. Mutations in the TLR5 gene have been linked with susceptibility to systemic lupus erythematosus and Legionnaire’s disease.Product Details
- Antibody Type
- Host Species
- Human TLR5 transfectants
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions. The solution is free of unconjugated Alexa Fluor® 647.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood.
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
View full statement regarding label licenses
- Excitation Laser
Red Laser (633 nm)
- Type 1 transmembrane protein, 98 kD
Neutrophils, classical monocytes, dendritic cells, mucosal epithelium
- Interacts with MyD88 and TRAF6 leading to NF-κB activation and production of cytokines.
- Cell Type
- Dendritic cells, Epithelial cells, Monocytes, Neutrophils
- Biology Area
- Molecular Family
- CD Molecules, Toll Like Receptors
- Antigen References
- Hayashi F, et al. 2001. Nature. 410:1099
- Gewirtz AT, et al. 2001. J Immunol. 167:1882
- Smith KD, et al. 2002. Curr Top Microbiol Immunol. 270:93
- Bambou JC, et al. 2004. J Biol Chem. 279:42984
- Sebastiani G, et al. 2000. Genomics. 64:230
- Muzio M, et al. 2000. Biochem Soc Trans. 28:563
- Gene ID
- 7100 View all products for this Gene ID
- View information about CD285 on UniProt.org
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.