- OX-7 (See other available formats)
- Other Names
- Thy-1, Thy-1.1
- Mouse IgG1, κ
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- Product Citations
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CD90, also known as Thy-1, is a 28-30 kD GPI-linked membrane glycoprotein. It is a member of the immunoglobulin superfamily and has been shown to interact with CD45 in signal transduction during lymphocyte proliferation and differentiation. CD90 is expressed on hematopoietic stem cells, neurons, thymocytes, peripheral T cells, fibroblasts, stromal cells.Product Details
- Rat, Mouse (AKR/J, PL, and FVBIN mouse strains), Cross-Reactivity: Rabbit (Lapine), Guinea Pig
- Antibody Type
- Host Species
- Rat thymocyte Thy-1 antigen
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 594 under optimal conditions. The solution is free of unconjugated Alexa Fluor® 594.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
IHC-F - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunohistochemical staining on frozen tissue sections. For immunohistochemistry, a concentration range of 5.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 594 has an excitation maximum of 590 nm, and a maximum emission of 617 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
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- Application Notes
The OX-7 antibody reacts with rat CD90 and mouse CD90.1 (Thy-1.1) (which is expressed by mouse strains of AKR/J, PL, and FVB/N), but not mouse CD90.2.
Additional reported applications (for the relevant formats) include: immunohistochemical7 and immunofluorescent8 staining of acetone-fixed frozen sections and zinc-fixed paraffin-embedded sections, immunoprecipitation1, Western blotting1, in vitro activation of leukocytes2, induction of endothelial cell permeability3, induction of apoptosis in glomerular mesangial cells, and induction of glomerulonephritis in vivo4.
(PubMed link indicates BioLegend citation)
- Jeng CJ, et al. 1998. J. Cell Biol. 140:685. (IP, WB)
- Nakashima I, et al. 1991. J. Immunol. 147:1153.
- Ishizu A, et al. 1995. Int. Immunol. 7:1939.
- Eitner F. 1997. Kidney. Int. 51:69.
- Kawachi H, et al. 1992. Clin. Exp. Immunol. 88:399. (WB)
- Dyer KD, et al. 2007. J. Immunol. 179:1693. (FC) PubMed
- Daniel C, et al. 2012. Lab Invest. 92:812. (IHC-P)
- Li B, et al. 2006. Kidney Int. 69:323. (ICC)
- Uchimura H, et al. 2005. J Am Soc Nephrol. 16(4):997-1004. (IHC-F)
- Inagi R, et al. 2008. J Am Soc Nephrol. 19(5):915-22. (IHC-P)
AB_2783139 (BioLegend Cat. No. 202545)
AB_2783140 (BioLegend Cat. No. 202546)
- Ig superfamily, GPI-anchored membrane glycoprotein, 28-30 kD
Hematopoietic stem cells, thymocytes, a subset of peripheral blood T cells, early myeloid and erythroid progenitors, immature B cells, neurons, activated endothelium, mast cells, dendritic cells, glomeruli
- Adhesion, signal transduction, lymphocyte co-stimulation, proliferation and differentiation of hematopoietic stem cells
- Ligand Receptor
- Interacts with CD45
- Cell Type
- B cells, Dendritic cells, Endothelial cells, Hematopoietic stem and progenitors, Mast cells, Neurons, T cells, Thymocytes
- Biology Area
- Molecular Family
- CD Molecules
- Antigen References
1. Campbell DG, et al. 1981. Biochem. J. 195:15.
2. Hosseinzadeh H, et al. 1993. J. Immunol. 150:1670.
- Gene ID
- 21838 View all products for this Gene ID 24832 View all products for this Gene ID
- View information about CD90.1 on UniProt.org
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