- In1/CD74 (See other available formats)
- Regulatory Status
- Other Names
- CLIP, DHLAG, HLADG
- Rat IgG2b, κ
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- Product Citations
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CD74, also known as CLIP, is a 33.5kD homotrimer and functions as a MHC class II chaperone for exogenous peptides and other MHC class II molecules. CD74 binds MIF and regulates innate and adaptive immunity through CD44 signaling. It is found primarily on B-cells, monocytes, macrophages and dendritic cells, but can also be found on activated T-cells, endothelial and epithelial cells.Product Details
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 594 under optimal conditions.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
IHC-F - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunohistochemical staining on frozen tissue sections. For immunohistochemistry, a concentration range of 5.0 - 10 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
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- Application Notes
This clone is also known as In1 and In-1. Additional reported applications (for the relevant formats) include: immunohistochemistry1, immunoprecipitation3, and western blotting4.
(PubMed link indicates BioLegend citation)
- Momburg F, et al. 1986. J. Immunol. 136:940. (IHC)
- Takahashi K, et al. 2009. Respir. Res. 10:33. (FC)
- Meza-Romero R, et al. 2014. J. Immunol. 192:4164. (IP)
- Heinrichs D, et al. 2011. Proc. Natl. Acad. Sci. USA 108:17444. (WB)
AB_2832531 (BioLegend Cat. No. 151007)
AB_2832532 (BioLegend Cat. No. 151008)
- 33.5 kD and homotrimer.
B-cells, monocytes/macrophages, dendritic cells, activated T-cells, and activated endothelial/epithelial cells.
- MHC class II chaperone, MHC class II molecule sorting, and peptide loading.
- MHC class II molecules and peptides.
- Macrophage migration inhibitory factor (MIF).
- Cell Type
- B cells, Dendritic cells, Endothelial cells, Epithelial cells, Macrophages, Monocytes, T cells
- Biology Area
- Molecular Family
- CD Molecules, MHC Antigens
- Antigen References
1. Herrero L, et al. 2013. Arthritis Rheum. 65:2724.
2. Geneve L, et al. 2012. Int. Immunol. 24:645.
3. Sille FC, et al. 2011. Immunol Lett. 139:33.
4. Shih NY, et al. 1995. Mol. Immunol. 32:643.
5. Shi X, et al. 2006. Immunity 25:595.
6. Starlets D, et al. 2006. Blood 107:4807.
- Gene ID
- 16149 View all products for this Gene ID
- View information about CD74 on UniProt.org
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