- HNK-1 (See other available formats)
- Regulatory Status
- Other Names
- HNK-1, NK-1, Leu-7
- Mouse IgM, κ
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- Product Citations
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CD57, also known as HNK-1, NK-1, and Leu-7 is a 100-115 kD oligosaccharide antigenic determinant expressed on a variety of proteins, lipids, and chondroitin sulfate proteoglycans. CD57 is expressed on a subset of peripheral blood lymphocytes, including NK cells and CD8+ T cells, and is also expressed on neural cells and striated muscle. CD57 is not expressed on red blood cells, granulocytes, monocytes, or platelets. While the function of CD57 is unknown, binding to L-selectin, P-selectin, and a fragment of laminin suggests that CD57 may be involved in cell-matrix interactions. CD57 is increased in some disease states associated with CD4/CD8 imbalances (AIDS, autoimmune disease, viral infections, and allograft transplants).Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Membrane extract of human lymphoblastoid cell line HSB-2.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 594 under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
IHC-P - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 594 has an excitation maximum of 590 nm, and a maximum emission of 617 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
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- Application Notes
Additional reported applications for the relevant formats include: Western blotting1.
(PubMed link indicates BioLegend citation)
- Yoshihara Y, et al. 1991. J. Cell Biol. 115:731. (WB)
- Abo T, et al. 1981. J. Immunol. 127:1024.
- Abo T, et al. 1982. J. Immunol. 129:1752.
- Abo T, et al. 1982. J. Immunol. 129:1758.
AB_2749946 (BioLegend Cat. No. 359625)
AB_2749947 (BioLegend Cat. No. 359626)
- Oligosaccharide antigenic determinant present on a variety of proteins, lipids, and chrondroitin sulfate proteoglycans, 100-115 kD. The antigen is conserved across species.
CD57 antigen is expressed on a subset of peripheral blood lymphocytes including a subset of NK cells and a subset of CD8+ T cells. Also expressed on neural cells and striated muscle.
- Unknown function, may be involved in cell-matrix interactions.
- Binds to L-selectin and P-selectin in a calcium-dependent manner, also binds to second globular domain of E8 laminin fragment.
- Cell Type
- Lymphocytes, NK cells, T cells
- Biology Area
- Immunology, Costimulatory Molecules
- Molecular Family
- CD Molecules
- Antigen References
1. Schubert J, et al. 1989. In Leucocyte Typing IV (Knapp W, ed) Oxford University Press Oxford pp 711-714.
2. Palmer BE, et al. 2005. J. Immunol. 175:8415.
3. Schachner M, et al. 1995. Trends Neurosci. 18:183.
4. Wood KL, et al. 2005. Clin. Immunol. 117:294.
- Gene ID
- 27087 View all products for this Gene ID
- View information about CD57 on UniProt.org
Related Pages & Pathways
Other FormatsView All CD57 Reagents Request Custom Conjugation
|Purified anti-human CD57||HNK-1||FC,IHC-P,WB|
|FITC anti-human CD57||HNK-1||FC|
|Pacific Blue™ anti-human CD57||HNK-1||FC|
|APC anti-human CD57||HNK-1||FC|
|PE anti-human CD57||HNK-1||FC|
|Alexa Fluor® 647 anti-human CD57||HNK-1||FC,IHC-P|
|Biotin anti-human CD57||HNK-1||FC|
|PE/Dazzle™ 594 anti-human CD57||HNK-1||FC|
|PerCP/Cyanine5.5 anti-human CD57||HNK-1||FC|
|PE/Cyanine7 anti-human CD57||HNK-1||FC|
|Alexa Fluor® 594 anti-human CD57||HNK-1||IHC-P|
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