Lymphotoxin-beta Receptor Pathway

Lymphotoxin-β receptors (LTβRs) are receptors expressed on many different cell types and can bind ligands such as LIGHT homotrimers and LTα1β2 expressed by hematopoietic stem cells. When engaged by LTα1β2, LTβR initiates signaling through TRAFs, activating NIK to ultimately cause NF-κB-driven gene expression. This pathway is important for formation of lymphoid structures such as germinal centers and Peyer's patches. LTβR can also be engaged by LIGHT, which activates caspase pathways to cause apoptosis.

 

Click on the poster below to view the interactive version.

 

Lymphotoxin-beta Receptor Pathway

ProductsHere
Insert Note Here
Save Close Clear
Lab Timer
Tools
Login / Register
Forgot your password? Reset password?
Create an Account