Soluble Receptors

Receptors bind to their respective ligands and recognize and respond to cell signals. They are a broad group which includes signaling receptors, non-signaling decoy receptors, receptor-associated proteins, and soluble receptors. Naturally occurring soluble receptors can be generated by several mechanisms, including proteolytic cleavage of surface-bound receptor ectodomains, alternative splicing of mRNA transcripts, transcription of distinct genes, cleavage of GPI-anchored receptors, and extracellular release of membrane-bound receptors within vesicles of exosomes.


One example is soluble cytokine receptors which once bound to cytokines can act as either agonists or antagonists of cytokine signaling. Our recombinant soluble receptors are constructed to encode only the extracellular domain and do not include the transmembrane or cytoplasmic domains.

Featured Data

Recombinant Mouse BAFFR (TNFRSF13C, CD268)- Fc Chimera (carrier-free)

 

 

Mouse BAFFR inhibits proliferation of mouse B cells induced by BAFF in a dose-dependent manner.

Recombinant Human sTNF-R1 (TNFRSF1A)

 

 

Inhibition of TNF-α-induced cytotoxicity in L929 cells by soluble TNF-R1.