Chemokines

Chemokines are relatively small cytokines which regulate cell movement, also known as chemotaxis. To mediate downstream functions, they bind to chemokine receptors which contain seven transmembrane domains. These receptors are typically promiscuous and bind to multiple chemokine ligands.

Chemokines contain several (typically four) cysteine residues in conserved positions within the protein (marked C in the image below) which provide tertiary structure through disulfide bonds. The spacing of the intervening amino acids (denoted X below) between the first two cysteine residues determine the type of chemokine.

 

 

Featured Data

Recombinant Mouse CCL2 (MCP-1) (carrier-free)

 

 

 

Mouse CCL2 attracts human monocytic THP-1 cells.

 

 

Recombinant Human CX3CL1 (Fractalkine) (carrier-free)

 

 

BaF3-mCX3CR1 transfectants attracted by human CX3CL1.