- W18021D (See other available formats)
- Regulatory Status
- Other Names
- Rat IgG2a, κ
- Ave. Rating
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- Product Citations
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CD62L is a 74-95 kD glycoprotein also known as L-selectin. It is a member of the selectin family and is expressed on the majority of B and naïve T cells, a subset of memory T cells, monocytes, granulocytes, most thymocytes, and a subset of NK cells. CD62L is important in lymphocyte homing to high endothelial venules (HEV) in peripheral lymph nodes and leukocyte "rolling" on activated endothelium. CD62L also contributes to neutrophil emigration at inflammatory sites. CD62L is rapidly shed from lymphocytes and neutrophils upon cellular activation and the expression levels of CD62L (in conjunction with other markers) have been used to distinguish naïve, effector, and memory T cells. CD62L has been reported to interact with CD34, GlyCAM-1, and MAdCAM-1.Product Details
- Antibody Type
- Host Species
- Mouse CD62L recombinant protein (39-332)
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Additional Product Notes
This clone does recognize CD62L in C57BL/6 and BALB/c.
- Product Citations
AB_2892330 (BioLegend Cat. No. 161202)
- CD62L is a type I transmembrane glycoprotein with 74-95 kD.
CD62L is expressed on the majority of B and naïve T cells, a subset of memory T cells, monocytes, granulocytes, most thymocytes, and a subset of NK cells.
- CD62L plays roles in lymphocyte homing to lymphoid organs and inflammatory leukocyte trafficking.
- CD34, GlyCAM-1, MAdCAM-1
- Antigen References
1. Rosen S. 2004. Annu. Rev. Immunol. 22:129
2. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
- Gene ID
- 20343 View all products for this Gene ID
- View information about CD62L on UniProt.org
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