- MB4B4 (See other available formats)
- Regulatory Status
- Other Names
- Rat IgG2a, κ
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- Product Citations
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CD45RB is a 220 kD single chain type I membrane glycoprotein. It is an exon 5 splice variant of the tyrosine phosphatase CD45. The CD45RB isoform is expressed on thymocytes, T cell subsets, B cells, monocytes/macrophages, granulocytes, and dendritic cells. CD45RB plays a critical role in TCR and BCR signaling. As T cells become activated and progress from naïve to memory cells, CD45RB expression is downregulated. Additionally, functionally distinct CD4+ T cell subsets, which secrete differing cytokine profiles, can be separated by CD45RB intensity. The primary ligands for CD45 are galectin-1, CD2, CD3, CD4 and Thy-1.Product Details
- Antibody Type
- Host Species
- anti-Ig activated murine B cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
(PubMed link indicates BioLegend citation)
- Birkeland ML, et al. 1988. J. Mol. Cell. Immunol. 4:71.
- Birkeland ML, et al. 1989. Proc. Natl. Acad. Sci. USA 86:6734.
- Lazarovits AI, et al. 1999. Kidney Int. 55:1303.
- Product Citations
AB_2572032 (BioLegend Cat. No. 151602)
- Tyrosine phosphatases, type I transmembrane, 220 kD (exon 5 splicing of CD45 gene).
Thymocytes, T cell subset, B cells, monocytes/macrophages, granulocytes, and dendritic cells.
- Enhances TCR and BCR signaling.
- Galectin-1, CD2, CD3, and CD4.
- Cell Type
- Thymocytes, T cells, B cells, Monocytes, Macrophages, Dendritic cells
- Biology Area
- Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers, Inhibitory Molecules
- Molecular Family
- CD Molecules
- Antigen References
1. Lee KM, et al. 2014. Cell Transplant. 23:51.
2. Kamanaka M, et al. 2011. J. Exp. Med. 208:1027.
3. Gagliani N, et al. 2011. PLoS One 6(12):e28434.
4. Ten Hove T, et al. 2004. J. Leuko. Biol. 75:1010.
5. Ogilvy S, et al. 2003. J. Immunol. 171:1792.
- Gene ID
- 19264 View all products for this Gene ID
- View information about CD45RB on UniProt.org
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