- IFNb/A1 (See other available formats)
- Other Names
- Interferon-β, Fibroblast interferon (Fi-IFN, F-IFN), Type-1 interferon, acid-stable interferon, R1-GI factor, IFN-b, IFN-beta
- Mouse IgG1, κ
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- Product Citations
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The IFNb/A1 clone recognizes natural human IFN-β and recombinants β1a and β1b.It is capable of neutralizing IFN-β.Product Details
- Human, epitope: Hu IFN-β site I, core peptide amino acid residues 32-56, AB loop (AB2, AB3)
- Antibody Type
- Host Species
- Recombinant HuIFN-β1b
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
ELISA, Neut - Reported in the literature
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 5 µg antibody per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Neutralization1: The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for neutralization of human IFN-β bioactivity (Cat. No. 514003).
Additional reported applications (for the relevant formats) include: ELISA1.
(PubMed link indicates BioLegend citation)
- Redlich PN and Grossberg SE, et al. 1989. J. Immunol. 143:1887. (ELISA, Neut)
- Redlich PN, et al. 1991. P. Natl. Acad. Sci. USA 88:4040.
- Runkel L, et al. 2001. IFN & Cytokine Res. 21:931.
- Product Citations
AB_2122765 (BioLegend Cat. No. 514002)
- Interferon; contains 187 amino acids with predicted molecular weight 22 kD.
- Non-specific humoral immune responses and immune responses against viral infections, increases expression of MHC class I antigens, blocks expression of MHC class II antigens stimulated by IFN-γ
- Cell Sources
- Fibroblasts, epithelial cells
- Cell Targets
- Broad, includes NK cells, T suppressor cells, activated monocytes
- IFNα/βR (IFNAR-1, IFNAR-2)
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Signal Transduction
- Molecular Family
- Antigen References
1. Nagarajan U, 2011. Crit. Rev. Immunol. 31:459.
2. Honda K, et al. 2005. Int. Immunol. 17:1367.
- Upregulated by viruses, double-stranded RNA, micro-organisms, TNF, IL-1
- Gene ID
- 3456 View all products for this Gene ID
- View information about IFN-beta on UniProt.org
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