Purified anti-human Granzyme K Antibody

Pricing & Availability
Clone
GM26E7 (See other available formats)
Other Names
Tryptase II, Granzyme-3, fragmentin-3, GZMK
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
GM26E7_Pure_GranzymeK_Antibody_121815
Human peripheral blood lymphocytes were fixed, permeabilized, and intracellularly stained with purified Granzyme K (clone GM26E7, filled histogram) or purified mouse IgG1, κ isotype control (open histogram) followed by anti-mouse IgG1 PE.
  • GM26E7_Pure_GranzymeK_Antibody_121815
    Human peripheral blood lymphocytes were fixed, permeabilized, and intracellularly stained with purified Granzyme K (clone GM26E7, filled histogram) or purified mouse IgG1, κ isotype control (open histogram) followed by anti-mouse IgG1 PE.
Cat # Size Price Quantity Avail. Save
370502 100 µg 164€
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Description

Granzyme K is a 29 kD serine protease found in cytoplasmic granules of cytotoxic lymphocytes and NK cells. Granzyme K is thought to induce cell death and lysis in response to non-self antigens on the cell surface by cleaving nucleosome assembly protein SET. Granzyme K is upregulated in several diseases associated with inflammation including arthritis, atherosclerosis, and asthma.

Product Details
Technical data sheet

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

ICFC - Quality tested
ICC - Reported in literature

Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2566673 (BioLegend Cat. No. 370502)

Antigen Details

Structure
Serine Protease, approximately 29 kD.
Distribution

Activated CD8+ cytotoxic T-cells, natural killer (NK) cells, and CD8+ T-cells.

Function
Cytotoxicity.
Interaction
SET
Cell Type
NK cells, T cells
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Neuroscience
Molecular Family
Enzymes and Regulators, Proteases
Antigen References

1. Vrazo AC, et al. 2015. Blood 126.
2. Cooper DM, et al. 2011. PLoS. One 6.
3. Wensink AC, et al. 2015. J. Immunol. 194:491.
4. Zhao T, et al. 2007. Cell Death Differ. 14:489.

Gene ID
3003 View all products for this Gene ID
UniProt
View information about Granzyme K on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 12.23.2015

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

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