Loading...

Purified anti-human CD57 Recombinant Antibody

Pricing & Availability
Clone
QA17A04 (See other available formats)
Regulatory Status
RUO
Other Names
HNK-1, NK-1, Leu-7, B3GAT1
Isotype
Mouse IgG1, κ
Ave. Rating
Submit a Review
Product Citations
publications
QA17A04_pure_CD56_Antibody_021518
Human peripheral blood lymphocytes were stained with purifed CD57 (clone QA17A04) (closed histogram), or mouse IgG1, κ purified isotype control (open histogram) followed by anti-mouse IgG1 PE.
  • QA17A04_pure_CD56_Antibody_021518
    Human peripheral blood lymphocytes were stained with purifed CD57 (clone QA17A04) (closed histogram), or mouse IgG1, κ purified isotype control (open histogram) followed by anti-mouse IgG1 PE.
  • QA17A04_pure_CD56_Antibody_IHCP_032422
    IHC staining using purified anti-CD57 antibody (clone QA17A04) on formalin-fixed paraffin-embedded human tonsil tissue. The tissue was incubated with 10 µg/mL of anti-CD57 antibody overnight at 4°C, followed by incubation with 2.5 µg/mL of Alexa Fluor® 647 goat anti-mouse IgM antibody (red) (Cat. No. 406526) for one hour at room temperature. Nuclei were counterstained with DAPI (blue) (Cat. No. 422801), and the slide was mounted with ProLong™ Gold Antifade Mountant. The image was captured with a 40x objective. Scalebar = 50 μM
Compare all formats
Cat # Size Price Quantity Check Availability Save
393302 100 µg 109€
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD57, also known as HNK-1, NK-1, and Leu-7 is a 100-115 kD oligosaccharide antigenic determinant expressed on a variety of proteins, lipids, and chondroitin sulfate proteoglycans. CD57 is expressed on a subset of peripheral blood lymphocytes, including NK cells and CD8+ T cells, and is also expressed on neural cells and striated muscle. CD57 is not expressed on red blood cells, granulocytes, monocytes, or platelets. While the function of CD57 is unknown, binding to L-selectin, P-selectin, and a fragment of laminin suggests that CD57 may be involved in cell-matrix interactions. CD57 is increased in some disease states associated with CD4/CD8 imbalances (AIDS, autoimmune disease, viral infections, and allograft transplants).

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Recombinant
Host Species
Mouse
Immunogen
Membrane extract of human lymphoblastoid cell line HSB-2.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

IHC-P - Verified
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µl volume. For immunohistochemistry, a concentration range of 1 - 10 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2749885 (BioLegend Cat. No. 393302)

Antigen Details

Structure
Oligosaccharide antigenic determinant present on a variety of proteins, lipds, and chrondroitin sulfate proteoglycans, 100-115 kD. The antigen is convserved across species.
Distribution

NK cells, subset of CD8+ T cells, neural cells, striated muscle

Ligand/Receptor
Binds to L-selectin and P-selectin in a calcium-dependent manner, also binds to second globular domain of E8 laminin fragment.
Cell Type
NK cells, T cells
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology
Molecular Family
CD Molecules
Antigen References
  1. Schubert J, et al. 1989. In Leucocyte Typing IV (Knapp W, ed) Oxford University Press Oxford pp 711-714.
  2. Palmer BE, et al. 2005. J. Immunol. 175:8415.
  3. Schachner M, et al. 1995. Trends Neurosci. 18:183.
  4. Wood KL, et al. 2005. Clin. Immunol. 117:294.
Gene ID
27087 View all products for this Gene ID
UniProt
View information about CD57 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 03.24.2022

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

  • Purified anti-human CD57 Recombinant Antibody

  • Brilliant Violet 605™ anti-human CD57 Recombinant Antibody

  • APC anti-human CD57 Recombinant Antibody

  • Brilliant Violet 510™ anti-human CD57 Recombinant Antibody

  • PerCP/Cyanine5.5 anti-human CD57 Recombinant Antibody

  • PE anti-human CD57 Recombinant Antibody

  • PE/Cyanine7 anti-human CD57 Recombinant Antibody

  • PE/Dazzle™ 594 anti-human CD57 Recombinant Antibody

  • TotalSeq™-C0168 anti-human CD57 Recombinant Antibody

  • TotalSeq™-A0168 anti-human CD57 Recombinant Antibody

  • TotalSeq™-B0168 anti-human CD57 Recombinant Antibody

  • Brilliant Violet 785™ anti-human CD57 Recombinant Antibody

  • Brilliant Violet 421™ anti-human CD57 Recombinant Antibody

  • Brilliant Violet 711™ anti-human CD57 Recombinant Antibody

  • TotalSeq™-D0168 anti-human CD57 Recombinant Antibody

ProductsHere
Login / Register
Remember me
Forgot your password? Reset password?
Create an Account