- Clone
- JS11 (See other available formats)
- Workshop
- VI N-L060
- Other Names
- DAF (Decay Accelerating Factor)
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood lymphocytes stained with purified JS11, followed by anti-mouse IgGs FITC
| Cat # | Size | Price | Quantity Avail. | Save | ||
|---|---|---|---|---|---|---|
| 311301 | 25 µg | 44€ | ||||
| 311302 | 100 µg | 80€ | ||||
CD55 is a 60-70 kD glycosylphosphatidylinositol (GPI)-anchored single chain glycoprotein also known as decay-accelerating factor (DAF). It is expressed on hematopoietic cells including erythrocytes and many non-hematopoietic cells. CD55 accelerates the dissociation of the components of the C3-convertases (namely C2a from C4b in the C4bC2a complex, a C3-convertase of the classical pathway, and factor Bb from the C3bBb complex, a C3-convertase of the alternative pathway) to protect cells from inappropriate damage caused by autologous complement. CD55 has been reported to reduce the efficiency of NK cell lysis and induce signal transduction in T cells. CD55 has also been shown to interact with CD97 and bind to Coxsackie and Echovirus.
Product DetailsProduct Details
- Reactivity
- Human, African Green, Baboon, Cynomolgus
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
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Application References
(PubMed link indicates BioLegend citation) -
- Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. London.
- Peyron P, et al. 2000. J. Immunol. 165:5186
- RRID
-
AB_314858 (BioLegend Cat. No. 311301)
AB_314859 (BioLegend Cat. No. 311302)
Antigen Details
- Structure
- GPI-achored regulator of complement activation (RCA), type I membrane glycoprotein, 60-70 kD
- Distribution
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Hematopoietic cells including erythrocytes and many non-hematopoietic cells
- Function
- Protects against inappropriate complement activation and cell damage, induces signal transduction, reduces the efficiency of NK cell lysis
- Ligand/Receptor
- C3b, C4b, CD97, Coxsackie viruses
- Biology Area
- Cell Biology, Immunology, Neuroinflammation, Neuroscience, Costimulatory Molecules
- Molecular Family
- CD Molecules
- Antigen References
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1. Schlossman S, et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York.
2. Hamann J, et al. 1996. J. Exp. Med. 184:1185.
3. Fujita T, et al. 1987. J. Exp. Med. 166:1221 - Gene ID
- 1604 View all products for this Gene ID
- UniProt
- View information about CD55 on UniProt.org
Related Pages & Pathways
Pathways
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