- A17070D (See other available formats)
- Regulatory Status
- Other Names
- Mouse IgG2b, κ
- Ave. Rating
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- Product Citations
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CD4, also known as T4/Leu-3, is a 55 kD single-chain type I transmembrane glycoprotein and member of the immunoglobulin superfamily. It is expressed on most thymocytes, helper T cells, type II NKT cells, and monocytes/macrophages. CD4 is part of the TCR/CD3 complex, binds to β2 domain from the MHC class II molecule, and participates in TCR signal transduction. CD4 is the receptor of IL-16 and is a coreceptor for the human immunodeficiency virus (HIV) and human herpes virus 7 (HHV-7).
- Antibody Type
- Host Species
- Recombinant human CD4
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
IHC-P - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5 - 10 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
AB_2888738 (BioLegend Cat. No. 396202)
- 55 kD, type I transmembrane glycoprotein, member of the Ig superfamily
Helper T cells, subset of thymocytes, monocytes/macrophages, type II NKT cells
- Part of the TCR/CD3 complex
- β2 domain from the MHC class II
- Antigen References
1. Zhu J, et al. 2010. Annu Rev. Immunol. 28:445.
2. Vignali DA. 2010. J. Immunol. 184:5933.
3. Zhou L, et al. 2009. Immunity 30:646.
4. Singer A, et al. 2008. Nat. Rev. Immunol. 8:788.
5. Zhu J and Paul WE. 2008. Blood 112:1557.
- Gene ID
- 920 View all products for this Gene ID
- View information about CD4 on UniProt.org
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