- GHI/75 (See other available formats)
- V B032
- Other Names
- ILT2, LIR-1, LILRB1, CD85
- Mouse IgG2b, κ
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- Product Citations
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CD85 is a group of Ig superfamily tansmembrane glycoproteins called Ig-Like Transcripts (ILTs) or Leukocyte Immunoglobulin-like Receptors (LIRs). CD85j is the 110kD member, known as ILT2, LIR1, or LILRB1, and MIR7. ILT2 structurally has four Ig domains and contains ITIMs in its cytoplasmic tail that provide inhibitory signals by recruiting SHP-1. ILT2 is found on the surface of B cells, plasma cells, dendritic cells, monocytes, subsets of NK and T cells. The ligands of ILT2 include a broad range of HLA-A, -B molecules, some HLA-C and HLA-G molecules, and the human cytomegalovirus UL18 protein.Product Details
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography and conjugated with PerCP/Cy5.5 under optimal conditions. The solution is free of unconjugated PerCP/Cy5.5 and unconjugated antibody.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
* PerCP/Cy5.5 has a maximum absorption of 482 nm and a maximum emission of 690 nm.
- Application Notes
Additional reported application: Block HLA-G induced TGF-β1 production.
- Additional Product Notes
- BioLegend is in the process of converting the name PerCP/Cy5.5 to PerCP/Cyanine5.5. The dye molecule remains the same, so you should expect the same quality and performance from our PerCP/Cyanine5.5 products. Contact Technical Service if you have any questions.
(PubMed link indicates BioLegend citation)
- Pulford K, et al. 1991. Clin. Exp. Immunol. 85:429
- Mclntire RH, et al. 2004. J. Leukoc. Biol. 76:1220
AB_2564607 (BioLegend Cat. No. 333713)
AB_2564608 (BioLegend Cat. No. 333714)
- ILT/LIR family, Ig superfamily, 110 kD
B cells, plasma cells, dendritic cells, monocytes, subsets of NK and T cells.
- Inhibitory receptor for MHC class I
- HLA-A, -B, some HLA-C and G molecules, human cytomegalovirus UL18 protein
- Cell Type
- B cells, Dendritic cells, Monocytes, NK cells, Plasma cells, T cells
- Biology Area
- Molecular Family
- CD Molecules
- Antigen References
1. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers Wiley-Liss A John Wiley & Sons Inc, Publication
2. Kirwan SE and Burshtyn DN. 2005. J. Immunol. 175:5006
- Gene ID
- 10859 View all products for this Gene ID
- View information about CD85 on UniProt.org
- How stable is PerCP/Cy5.5 tandem as compared to PerCP alone?
- PerCP/Cy5.5 is quite photostable and also better than PerCP alone in withstanding fixation.
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