- SA222C5 (See other available formats)
- Regulatory Status
- Other Names
- G-Protein coupled receptor 49 (GPR49), G-Protein coupled receptor 67 (GPR67), FEX, HG38
- Mouse IgG2a, κ
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- Product Citations
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LGR5, also known as GPR49, is a 100 KD protein. It is a member of GPCR class A orphan receptor proteins which binds R-spondin and does not activate through heterotrimeric G protein like other GPCR. It triggers the Wnt signaling pathway downstream. LGR5 is expressed across a diverse range of tissue such as in the muscle, placenta, spinal cord and brain and particularly as a biomarker of adult stem cells in certain tissues.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Human LGR5 transfectant cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
AB_2922590 (BioLegend Cat. No. 373807)
AB_2922590 (BioLegend Cat. No. 373808)
- G-protein coupled receptor (GPCR) superfamily
Muscle, placenta, spinal cord, brain and particularly as a biomarker of adult stem cells in certain tissues
- Triggers Wnt signaling pathway
- Wnt pathway
- R-spondins (RSpo 1,2,3, and 4)
- Biology Area
- Antigen References
- Hsu Sy, et al. 1998. Mol. Endocrinol. 12:1830.
- Barker N, et al. 2007. Nature. 449:1003.
- Morita H, et al. 2004. Mol. Cell. Biol. 24(22):9736.
- Arioka Y, et al. 2017. Stem Cell Res. 20:1.
- Wang B, et al. 2016. Plos. One. 11:e0168904.
- Garcia MI, et al. 2009. Dev. Biol. 331:58.
- Gene ID
- 8549 View all products for this Gene ID
- View information about LGR5 on UniProt.org
Related Pages & Pathways
Other FormatsView All LGR5 Reagents Request Custom Conjugation
|Purified anti-human LGR5 (GPR49)||SA222C5||FC|
|PE anti-human LGR5 (GPR49)||SA222C5||FC|
|APC anti-human LGR5 (GPR49)||SA222C5||FC|
|PE/Dazzle™ 594 anti-human LGR5 (GPR49)||SA222C5||FC|
|PE/Cyanine7 anti-human LGR5 (GPR49)||SA222C5||FC|
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