PE anti-human CD271 (NGFR) Antibody

Pricing & Availability
ME20.4 (See other available formats)
Regulatory Status
Other Names
p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, NGFR, Nerve Growth Factor Receptor
Mouse IgG1, κ
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Product Citations
Human neuroblastoma cell line SK-N-MC stained with ME20.4 PE
  • ME20dot4_PE_021810
    Human neuroblastoma cell line SK-N-MC stained with ME20.4 PE
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345105 25 tests 123€
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345106 100 tests 244€
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CD271, also known as p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, and NGFR, is a type I transmembrane protein with a MW of 75 kD. It is expressed by many cell types including neurons, Schwann cells, mesenchymal stem/stromal cells, follicular dendritic cells and melanocytes. The extracellular portion contains four TNFR-Cys repeats that form the binding domain for its ligands (NGF, BDNF, NTF3, and NTF4). The intracellular portion of CD271 contains a death domain, which interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9, to promote cell apoptosis, and to regulate cell differentiation and neurogenesis.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Host Species
WM245 melanoma cells
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications for the relevant formats include: immunoprecipitation1, Western blotting4, immunohistochemical staining of frozen or paraffin embedded tissue sections1,2, and blocking of NGF binding1.

Application References

(PubMed link indicates BioLegend citation)
  1. Ross A, et al. 1984. P. Natl. Acad. Sci. USA 81:6681. (FC, IP, Block, IHC)
  2. Cattoretti G, et al. 1993. Blood 81:1726. (IHC)
  3. Kamke MR, et al. 2005. Hear Res. 206:89.
  4. Baker D, et al. 1989. Cancer Res. 49:4142-4146. (FC, WB)
Product Citations
  1. Veraitch O, et al. 2017. Sci Rep. 7:42777. PubMed
  2. Hirai T, et al. 2020. Immunity. 54(1):84-98.e5. PubMed
  3. Carraro G, et al. 2020. Am J Respir Crit Care Med. 202:1540. PubMed
  4. Leimkühler NB, et al. 2020. Cell Stem Cell. 28:637. PubMed
  5. Peng S et al. 2019. Cell Rep. 28(10):2728-2738 . PubMed
  6. Vaidyanathan S, et al. 2020. Cell Stem Cell. 26(2):161-171.e4.. PubMed
  7. Gerhauser C et al. 2018. Cancer cell. 34(6):996-1011 . PubMed
  8. Banerjee AK, et al. 2020. Cell. 1325:183. PubMed
  9. Kenswil KJG, et al. 2021. Cell Stem Cell. 28(4):653-670.e11. PubMed
  10. Henry GH et al. 2018. Cell reports. 25(12):3530-3542 . PubMed
  11. Crowell PD et al. 2019. Cell Rep. 28(6):1499-1510 . PubMed
  12. Lee L, et al. 2016. PLoS One. 11:e0167693. PubMed
  13. Fujii S, et al. 2019. Stem Cells Dev. 28:28. PubMed
  14. Toshiro Hirai et al. 2019. Immunity. 50(5):1249-1261 . PubMed
  15. Daltoe FP, et al. 2020. Braz Oral Res. 34:e033. PubMed
  16. Loo CS, et al. 2020. Immunity. 53:143. PubMed
  17. Dupont L, et al. 2021. Cell Host Microbe. 29(5):792-805.e6. PubMed
  18. Su Y et al. 2019. PLoS Comput Biol. 15(6):e1007034 . PubMed
  19. Asada S, et al. 2018. Nat Commun. 9:2733. PubMed
  20. Barone C, et al. 2020. Glia. . PubMed
  21. Deng P, et al. 2020. Bone Res. 8:39. PubMed
AB_2282827 (BioLegend Cat. No. 345105)
AB_2152647 (BioLegend Cat. No. 345106)

Antigen Details

Type I transmembranal protein with a MW of 75 kD. The extracellular portion contains four TNFR-Cys repeats that form the NGF binding domain; the intracellular portion contains a death domain.

Expressed by many cell types including neurons, Schwann cells, mesenchymal stem/stromal cells, follicular dendritic cells, melanocytes.

Apoptosis, differentiation, neurogenesis.
Nerve growth factor (NGF), Brain-derived neurotrophic factor (BDNF), Neurotrophin 3. (NTF3) , Neurotrophin 4 (NTF4)
Apoptosis, differentiation, neurogenesis.
Cell Type
Dendritic cells, Mesenchymal cells, Mesenchymal Stem Cells, Neurons
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Neuroscience, Stem Cells, Synaptic Biology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, Postsynaptic proteins
Antigen References

1. Friedman MJ, et al. 2009. J. Biol. Chem. 284:27944.
2. Rock JR, et al. 2009. Proc Natl Acad Sci USA. 106:12771.
3. Kidd SK, et al. 2008. Brain Res.1195:113.
4. Peters EM, et al. 2007. Am J Pathol. 171:1872.
5. Jansen P, et al. 2007. Nat Neurosci. 10:1449.

Gene ID
4804 View all products for this Gene ID
View information about CD271 on

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11.30.2012

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

  • Purified anti-human CD271 (NGFR)

  • FITC anti-human CD271 (NGFR)

  • PE anti-human CD271 (NGFR)

  • APC anti-human CD271 (NGFR)

  • PE/Cyanine7 anti-human CD271 (NGFR)

  • PerCP/Cyanine5.5 anti-human CD271 (NGFR)

  • Alexa Fluor® 647 anti-human CD271 (NGFR)

  • Alexa Fluor® 700 anti-human CD271 (NGFR)

  • PE/Dazzle™ 594 anti-human CD271 (NGFR)

  • APC/Fire™ 750 anti-human CD271 (NGFR)

  • Biotin anti-human CD271 (NGFR)

  • TotalSeq™-A0816 anti-human CD271 (NGFR)

  • APC/Cyanine7 anti-human CD271 (NGFR)

  • TotalSeq™-C0816 anti-human CD271 (NGFR)

  • TotalSeq™-B0816 anti-human CD271 (NGFR)

  • Pacific Blue™ anti-human CD271 (NGFR) Antibody

  • TotalSeq™-D0816 anti-human CD271 (NGFR)


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