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PE anti-human CD108 Antibody

Pricing & Availability
Clone
MEM-150 (See other available formats)
Regulatory Status
RUO
Workshop
HCDM listed
Other Names
JMH blood group antigen, semaphorin 7A, H-SEMA, SEMAL
Isotype
Mouse IgM, κ
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Product Citations
publications
MEM-150_PE_070507
PHA-stimulated human peripheral blood mononuclear cells (day-3) stained with MEM-150 PE
  • MEM-150_PE_070507
    PHA-stimulated human peripheral blood mononuclear cells (day-3) stained with MEM-150 PE
See PE spectral data
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315704 100 tests 215€
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Description

CD108 is an 80 kD GPI-linked membrane-bound semaphorin, also known as JMH blood group antigen, semaphorin 7A, H-SEMA, and SEMAL. It contains an Ig-like domain and is expressed at low levels on erythrocytes and lymphocytes. The expression of CD108 on lymphocytes is upregulated upon activation. CD108 is a guidance protein known for immunomodulatory effects that has been shown to enhance central and peripheral axon growth. CD108 interacts with plexin C1. The MEM-150 antibody has been shown to be useful for flow cytometry, Western blotting, and immunoprecipitation.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Human
Immunogen
HPB-ALL T cell line
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Additional reported applications (for the relevant formats) include: immunoprecipitation, Western blotting (non reducing).

Application References

(PubMed link indicates BioLegend citation)
  1. Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. New York.
  2. Angelisovß P, et al. 1999. Immunobiology 200:234.
RRID
AB_2186144 (BioLegend Cat. No. 315704)

Antigen Details

Structure
Membrane bound semaphorin with GPI-linkage, contains Ig-like domain, approximately 80 kD
Distribution

Widely expressed in spleen, thymus, testis, ovary, heart, lung, kidney, brain, small intestine, red cells, monocytes, and T cells

Function
Guidance protein known for immunomodulatory effects, enhances central and peripheral axon growth and is required for proper axon tract formation
Interaction
Plexin C1
Modification
Glycosylated, myristoylated
Cell Type
Erythrocytes, Monocytes, T cells
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Leukocyte Typing V. Schlossman S, et al. (eds) Oxford University Press (1995)
2. Pasterkamp RJ, et al. 2003. Nature 424:398.
3. Xu X, et al. 1998. J. Biol. Chem. 273:22428.
4. Sato Y, et al. 1998. Biochim. Biophys. Acta 1443:419.

Gene ID
8482 View all products for this Gene ID
UniProt
View information about CD108 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11.30.2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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