- A7R34 (See other available formats)
- Regulatory Status
- Other Names
- IL-7 receptor α chain, IL-7Rα
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
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CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be an useful marker for identifying memory and effector T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cells proliferation and development.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- IL-7Ra-IgG1 fusion protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
- The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421™ under optimal conditions.
- µg sizes: 0.2 mg/mLµL sizes: lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining using the µg size, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. For immunofluorescent staining using µl sizes, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Brilliant Violet 421™ excites at 405 nm and emits at 421 nm. The standard bandpass filter 450/50 nm is recommended for detection. Brilliant Violet 421™ is a trademark of Sirigen Group Ltd.
Learn more about Brilliant Violet™.
This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.
- Excitation Laser
Violet Laser (405 nm)
- Application Notes
A7R34 is able to block clone SB/199 binding to IL-7R.
- Additional Product Notes
View more applications data for this product in our Scientific Poster Library.
(PubMed link indicates BioLegend citation)
- Product Citations
AB_10897948 (BioLegend Cat. No. 135023)
AB_2563103 (BioLegend Cat. No. 135027)
AB_11218800 (BioLegend Cat. No. 135024)
- Type I transmembrane glycoprotein, associate with CD132, 60-90 kD
Immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, bone marrow stromal cells
- T cell and immature B cell proliferation and development
- Cell Type
- B cells, T cells, Thymocytes
- Biology Area
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
1. Sudo T, et al. 1993. P. Natl. Acad. Sci. USA 90:9125.
2. Okuno Y, et al. 2001. P. Natl. Acad. Sci. USA 99:6246.
3. Pillai M, et al. 2004. Leukemia Lymphoma 45:2403.
- Gene ID
- 16197 View all products for this Gene ID
- View information about CD127 on UniProt.org
- What is the F/P ratio range of our BV421™ format antibody reagents?
It is lot-specific. On average it ranges between 2-4.
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-mouse CD127 (IL-7Rα)
FITC anti-mouse CD127 (IL-7Rα)
PE anti-mouse CD127 (IL-7Rα)
APC anti-mouse CD127 (IL-7Rα)
PE/Cyanine7 anti-mouse CD127 (IL-7Rα)
PE/Cyanine5 anti-mouse CD127 (IL-7Rα)
Alexa Fluor® 488 anti-mouse CD127 (IL-7Rα)
Alexa Fluor® 647 anti-mouse CD127 (IL-7Rα)
PerCP/Cyanine5.5 anti-mouse CD127 (IL-7Rα)
Biotin anti-mouse CD127 (IL-7Rα)
Brilliant Violet 421™ anti-mouse CD127 (IL-7Rα)
Brilliant Violet 605™ anti-mouse CD127 (IL-7Rα)
Purified anti-mouse CD127 (IL-7Rα) (Maxpar® Ready)
PE/Dazzle™ 594 anti-mouse CD127 (IL-7Rα)
Brilliant Violet 510™ anti-mouse CD127 (IL-7Rα)
Brilliant Violet 711™ anti-mouse CD127 (IL-7Rα)
Brilliant Violet 785™ anti-mouse CD127 (IL-7Rα)
APC/Cyanine7 anti-mouse CD127 (IL-7Rα)
Brilliant Violet 650™ anti-mouse CD127 (IL-7Rα)
TotalSeq™-A0198 anti-mouse CD127 (IL-7Rα)
TotalSeq™-C0198 anti-mouse CD127 (IL-7Rα)
Ultra-LEAF™ Purified anti-mouse CD127 (IL-7Rα)
TotalSeq™-B0198 anti-mouse CD127 (IL-7Rα)