Brilliant Violet 421™ anti-human LOX-1 Antibody

Pricing & Availability
15C4 (See other available formats)
Regulatory Status
Other Names
Mouse IgG2a, κ
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Product Citations
GM-CSF-stimulated (3 days) human peripheral blood monocytes were stained with LOX-1 (clone 15C4) Brilliant Violet 421™ (filled histogram) or mouse IgG2a, κ Brilliant Violet 421™ isotype control (open histogram).
  • 15C4_BV421_LOX-1_Antibody_032118
    GM-CSF-stimulated (3 days) human peripheral blood monocytes were stained with LOX-1 (clone 15C4) Brilliant Violet 421™ (filled histogram) or mouse IgG2a, κ Brilliant Violet 421™ isotype control (open histogram).
Compare all formats See Brilliant Violet 421™ spectral data
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358609 25 tests 164€
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358610 100 tests 348€
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Lectin-like oxidized LDL receptor 1 (LOX-1) also known as CLEC8A is a 31 kD single pass type II transmembrane protein and member of the C-type lectin superfamily. LOX-1 is a scavenger receptor and is involved in endocytosis, phagocytosis and cytokine production. CLEC8A is expressed by endothelial cells, smooth muscle cells, platelets, fibroblasts, macrophages, and is upregulated by inflammatory and oxidative stimuli. LOX-1 recognizes numerous ligands including lipoproteins, apoptotic cells heat shock proteins, C-reactive protein and oxidized LDL. LOX-1 is implicated in atherosclerosis and vascular inflammation.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Antibody Type
Host Species
LOX-1 ectodomain: Fc fusion protein
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421™ under optimal conditions.
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Brilliant Violet 421™ excites at 405 nm and emits at 421 nm. The standard bandpass filter 450/50 nm is recommended for detection. Brilliant Violet 421™ is a trademark of Sirigen Group Ltd.

Learn more about Brilliant Violet™.

This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.
Excitation Laser
Violet Laser (405 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunofluorescent staining of acetone-fixed frozen human skin sections1.

Application References

(PubMed link indicates BioLegend citation)
  1. Li D, et al. 2012. J. Exp. Med. 209:109. (IHC)
Product Citations
  1. Emmons TR, et al. 2021. Cancer Immunol Res. 9:790. PubMed
  2. Koh J, et al. 2020. Eur J Immunol. 50:1810. PubMed
AB_2728342 (BioLegend Cat. No. 358609)
AB_2728343 (BioLegend Cat. No. 358610)

Antigen Details

Single pass, type II, transmembrane protein, 31 kD, homodimer, member of the C-type lectin superfamily.
Endothelial cells, smooth muscle, platelets, fibroblasts, macrophages; Upregulated by inflammatory and oxidative stimuli
Scavenger receptor, involved in endocytosis, phagocytosis and cytokine production
Recognizes numerous ligands including lipoproteins, apoptotic cells, heat shock proteins, C-reactive protein, oxidized LDL
Cell Type
Endothelial cells, Platelets, Fibroblasts, Macrophages, Dendritic cells
Biology Area
Cell Adhesion, Cell Biology, Immunology, Innate Immunity
Molecular Family
Adhesion Molecules
Antigen References

1. Yin Y, et al. 2013. Eur. J. Cell Biol. 92:150. 
2. Khaidakov M. and Mehta JL. 2012. PLoS One. 7:e46973. 
3. Sawamura T, et al. 2012. Curr. Opin. Lipidol. 23:439. 
4. Lin FY, et al. 2011. J. Immunol. 186:4405. 
5. Parlato S, et al. 2010. Blood 115:1554.

Gene ID
4973 View all products for this Gene ID
View information about LOX-1 on

Related FAQs

What is the F/P ratio range of our BV421™ format antibody reagents?

It is lot-specific. On average it ranges between 2-4.

Go To Top Version: 0    Revision Date: 03.21.2018

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.


*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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