- RCR-16 (See other available formats)
- Other Names
- Endothelial protein C receptor, protein C receptor, PROCR, activated protein C receptor, APC receptor
- Rat IgG2a, κ
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- Product Citations
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Endothelial protein C receptor (EPCR), also known as CD201, is a 46 kD N-glycosylated type I transmembrane protein, primarily expressed on the endothelial cells of arteries and veins in heart and lung. It is also expressed at high levels on a subset of hematopoietic stem cells and a subset of dendritic cells. CD201 functions as a primary receptor for protein C activation, and results in inhibition of both intrinsic and extrinsic coagulation pathways. It also plays an important role in many pathophysiologic processes, such as inflammation responses to infection, trauma, hematopoiesis, and autoimmune response. Deletion of the CD201 gene in knock-out mice leads to embryonic lethality before embryonic day 10, indicating that CD201 expression is critical for embryo development. In humans, mutations of CD201 have been associated with venous thromboembolism and myocardial infarction as well as with late fetal loss during pregnancy.Product Details
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications (for the relevant formats) include: in vivo and in vitro blocking of protein C binding1.
(PubMed link indicates BioLegend citation)
- Centelles MN, et al. 2010. Thromb Haemost. 103:1239. (Block)
- Product Citations
AB_11219198 (BioLegend Cat. No. 141507)
AB_11218997 (BioLegend Cat. No. 141508)
- Type I transmembrane glycoprotein, 46 kD
Endothelial cells, subset of hematopoietic stem cells, subset of dendritic cells
- Inhibits blood coagulation, apoptosis, inflammation, endothelial activation
- Protease-activated receptor 1 (Par-1)
- Protein C, activated protein C
- Cell Type
- Dendritic cells, Endothelial cells, Hematopoietic stem and progenitors
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Costimulatory Molecules
- Molecular Family
- CD Molecules
- Antigen References
1. Kerschen E, et al. 2010. J. Clin. Invest. 120:3167.
2. Iwasaki H, et al. 2010. Blood 116:544.
3. Balazs AB, et al. 2006. Blood 107:2317.
- Gene ID
- 19124 View all products for this Gene ID
- View information about CD201 on UniProt.org
- How many biotin molecules are per antibody structure?
- We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
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