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Biotin anti-mouse CD170 (Siglec-F) Antibody

Pricing & Availability
Clone
S17007L (See other available formats)
Regulatory Status
RUO
Other Names
Siglec-5
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
S17007L_Biotin_CD170_Antibody_071019
C57BL/6 mouse splenocytes were stained with CD193 (CCR3, clone J073E5) APC and biotinylated Siglec-F (clone S17007L, left) or biotinylated rat IgG2a, κ isotype control (right), followed by SAV- PE
  • S17007L_Biotin_CD170_Antibody_071019
    C57BL/6 mouse splenocytes were stained with CD193 (CCR3, clone J073E5) APC and biotinylated Siglec-F (clone S17007L, left) or biotinylated rat IgG2a, κ isotype control (right), followed by SAV- PE
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155512 100 µg 109€
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Description

CD170, also known as Siglec-F, Siglec-5, is a member of the Sialic acid-binding Ig-like lectin family, type I single pass transmembrane protein, with 4 extracellular Ig-like domains and 2 ITIM motifs in the cytoplasmic domain; preferentially binds [alpha]-2,3-linked sialic acid. Siglec F is expressed in eosinophils, alveolar macrophages and intestinal microfold (M) cells and induces apoptosis of the lung eosinophis during allergic asthma.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2814066 (BioLegend Cat. No. 155512)

Antigen Details

Structure
Member of the Sialic acid-binding Ig-like lectin family, type I, single pass, transmembrane protein, 4 extracellular Ig-like domains, 2 ITIM motifs in the cytoplasmic domain
Distribution

Eosinophils, alveolar macrophages, intestinal microfold (M) cells

Function
Induces apoptosis in eosinophils
Ligand/Receptor
[alpha]-2,3-linked sialic acid
Cell Type
Eosinophils, Macrophages
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Innate Immunity
Molecular Family
CD Molecules, Siglec Molecules
Antigen References
  1. Gicheva N, et al. 2016. Biochem. Biophys. Res. Commun. 479:1.
  2. Kiwamoto T, et al. 2015. J. Allergy Clin. Immunol. 135:1329.
  3. Suzukawa M, et al. 2013. J. Immunol. 190:5939.
  4. Patnode ML, et al. 2013. J. Biol. Chem. 288:26533.
Gene ID
233186 View all products for this Gene ID
UniProt
View information about CD170 on UniProt.org

Related FAQs

How many biotin molecules are per antibody structure?
We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
Go To Top Version: 1    Revision Date: 07.10.2019

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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