- GHI/75 (See other available formats)
- V B032
- Other Names
- ILT2, LIR-1, LILRB1, CD85
- Mouse IgG2b, κ
- Ave. Rating
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- Product Citations
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CD85 is a group of Ig superfamily tansmembrane glycoproteins called Ig-Like Transcripts (ILTs) or Leukocyte Immunoglobulin-like Receptors (LIRs). CD85j is the 110kD member, known as ILT2, LIR1, or LILRB1, and MIR7. ILT2 structurally has four Ig domains and contains ITIMs in its cytoplasmic tail that provide inhibitory signals by recruiting SHP-1. ILT2 is found on the surface of B cells, plasma cells, dendritic cells, monocytes, subsets of NK and T cells. The ligands of ILT2 include a broad range of HLA-A, -B molecules, some HLA-C and HLA-G molecules, and the human cytomegalovirus UL18 protein.Product Details
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported application: Block HLA-G induced TGF-β1 production.
(PubMed link indicates BioLegend citation)
- Pulford K, et al. 1991. Clin. Exp. Immunol. 85:429
- Mclntire RH, et al. 2004. J. Leukoc. Biol. 76:1220
- Product Citations
AB_1089083 (BioLegend Cat. No. 333706)
- ILT/LIR family, Ig superfamily, 110 kD
B cells, plasma cells, dendritic cells, monocytes, subsets of NK and T cells.
- Inhibitory receptor for MHC class I
- HLA-A, -B, some HLA-C and G molecules, human cytomegalovirus UL18 protein
- Cell Type
- B cells, Dendritic cells, Monocytes, NK cells, Plasma cells, T cells
- Biology Area
- Molecular Family
- CD Molecules
- Antigen References
1. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers Wiley-Liss A John Wiley & Sons Inc, Publication
2. Kirwan SE and Burshtyn DN. 2005. J. Immunol. 175:5006
- Gene ID
- 10859 View all products for this Gene ID
- View information about CD85 on UniProt.org
- How many biotin molecules are per antibody structure?
- We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
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