- B1 (See other available formats)
- Regulatory Status
- Other Names
- T cell receptor γ/δ, γ/δ TCR, TCR-γ/δ
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
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T cell receptor (TCR) is a heterodimer consisting of an α and a β chain (TCR α/β) or a γ and a δ chain (TCR γ/δ). TCR γ/δ is involved in the recognition of certain bacterial, self-CD1 molecule, and tumor antigens bound to MHC class I. The γ/δ TCR associates with CD3 and is expressed on a subset of T cells found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most γ/δ T cells are CD4-/CD8-, some are CD8+. T cells expressing the γ/δ TCR have been shown to play a role in oral tolerance, innate immune response for some tumor cells, and autoimmune disease. It has been reported that γ/δ T cells also play a principal role in antigen presentation.Product Details
- Verified Reactivity
- Human, Cynomolgus, Rhesus
- Reported Reactivity
- African Green, Baboon, Pigtailed Macaque
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with APC/Fire™ 750 under optimal conditions.
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
* APC/Fire™ 750 has a maximum excitation of 650 nm and a maximum emission of 787 nm.
- Application Notes
Clone B1 is also known as clone B1.1.
Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections3 and paraffin-embedded sections5, in vitro blocking, and spatial biology (IBEX)8,9. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for highly sensitive assays (Cat. Nos. 331235 and 331236).
(PubMed link indicates BioLegend citation)
- Rodriguez-Gago M, et al. 2001. Transplantation. 72:503.
- Lehmann FS, et al. 2002. Am. J. Physiol. Gastrointest. Liver. Physiol. 283:G481. (FC)
- Bordignon M, et al. 2008. Mol. Med. Rep. 1:485. (IHC)
- Conrad M, et al. 2007. Cytom. Part A 71A:925. (FC)
- Pollinger B, et al. 2011. J. Immunol. 186:2602. (IHC)
- Correia DV, et al. 2011. Blood. 118:992. (Block)
- Laurent AJ, et al. 2014. PLoS One. 9:103683. PubMed
- Radtke AJ, et al. 2020. Proc Natl Acad Sci USA. 117:33455-33465. (SB) PubMed
- Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
- Product Citations
AB_2650626 (BioLegend Cat. No. 331227)
AB_2650627 (BioLegend Cat. No. 331228)
- Ig superfamily, associates with CD3 complex
T subset in thymus, intestinal epithelium, peripheral lymphoid tissues and peritoneum
- Antigen recognition
- Some bacterial or tumor antigens bound MHC class I, CD1 molecule
- Cell Type
- Epithelial cells, T cells
- Biology Area
- Adaptive Immunity, Immunology
- Molecular Family
- Antigen References
1. Lanier LL, et al. 1987. J. Clin. Immunol. 7:429.
2. Spencer J, et al. 1989. Eur. J. Immunol. 19:1335.
3. Uyemura K, et al. 1991. J. Exp. Med. 174:683.
4. Spada FM, et al. 2000. J. Exp. Med. 191:907.
- Gene ID
- 6964 View all products for this Gene ID 6965 View all products for this Gene ID
- View information about TCR gamma/delta on UniProt.org
Related Pages & Pathways
Other FormatsView All TCR γ/δ Reagents Request Custom Conjugation
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-human TCR γ/δ
Biotin anti-human TCR γ/δ
FITC anti-human TCR γ/δ
PE anti-human TCR γ/δ
APC anti-human TCR γ/δ
Alexa Fluor® 647 anti-human TCR γ/δ
Brilliant Violet 421™ anti-human TCR γ/δ
Brilliant Violet 510™ anti-human TCR γ/δ
PE/Cyanine7 anti-human TCR γ/δ
PerCP/Cyanine5.5 anti-human TCR γ/δ
PE/Dazzle™ 594 anti-human TCR γ/δ
APC/Fire™ 750 anti-human TCR γ/δ
TotalSeq™-A0139 anti-human TCR γ/δ
TotalSeq™-C0139 anti-human TCR γ/δ
TotalSeq™-B0139 anti-human TCR γ/δ
Ultra-LEAF™ Purified anti-human TCR γ/δ
PE/Fire™ 700 anti-human TCR γ/δ Antibody
Alexa Fluor® 660 anti-human TCR γ/δ Antibody
TotalSeq™-D0139 anti-human TCR γ/δ