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APC anti-human CD41 Antibody

Pricing & Availability
Clone
HIP8 (See other available formats)
Regulatory Status
RUO
Workshop
IV P38
Other Names
gpIIb, CD41a
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
HIP8
Human platelets stained with HIP8 PE
  • HIP8
    Human platelets stained with HIP8 PE
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303709 25 tests 112€
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303710 100 tests 253€
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Description

CD41 is a 125/25 kD α subunit of the gpIIb/IIIa (CD41/CD61) complex. CD41 is a heterodimer composed of a heavy chain (gpIIbα) and light chain (gpIIbβ) linked by a single disulfide bond. It is a member of the integrin family primarily expressed on platelets and megakaryocytes. CD41 has been reported to be involved with platelet aggregation and platelet attachment to the ECM. CD41/CD61 complex acts as the receptor for fibrinogen, fibronectin, Von Willebrand factor, and thrombin.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Capuchin Monkey, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections and blocking of platelet aggregation2. The HIP8 antibody has been reported to block the activation of platelets by various stimuli, including collagen, and ADP.

Application References

(PubMed link indicates BioLegend citation)
  1. Knapp W, et al. 1989. Leucocyte Typing IV. Oxford University Press. New York.
  2. McCarty OJT, et al. 2000. Blood 96:1789.
  3. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
  4. Zhi L et al. 2013. PLoS One. 8:e79869. (IHC)
Product Citations
  1. Liu Y, et al. 2022. Signal Transduct Target Ther. 7:347. PubMed
  2. Machata S, et al. 2021. Front Immunol. 11:565869. PubMed
  3. Moussa M, et al. 2016. J Biomater Appl. 30: 1219 - 1229. PubMed
  4. Botha J, et al. 2021. Biomedicines. 9:. PubMed
  5. Pircher J, et al. 2018. Nat Commun. 32:364. PubMed
  6. Wang B, et al. 2022. Cell Discov. 8:41. PubMed
  7. Best MG et al. 2017. Cancer cell. 32(2):238-252 . PubMed
  8. Hug S, et al. 2021. Front Immunol. 12:642867. PubMed
  9. Sung PS, et al. 2019. Nat Commun. 10:2402. PubMed
  10. Sato M, et al. 2021. Spine Surg Relat Res. 5:196. PubMed
  11. Rodda LB, et al. 2020. Cell. 184(1):169-183.e17. PubMed
  12. Zhang G, et al. 2021. Front Pharmacol. 12:705325. PubMed
  13. Shlamkovich T, et al. 2020. BMC Biology. 16(1):92. PubMed
  14. Pellin D, et al. 2019. Nat Commun. 10:2395. PubMed
  15. Ito Y, et al. 2018. Cell. 174:636. PubMed
  16. Palacios-Acedo AL, et al. 2021. Front Oncol. 11:704945. PubMed
  17. Guo Q, et al. 2022. Blood Adv. 6:5668. PubMed
  18. Suzuki D, et al. 2020. Stem Cell Reports. 14:49. PubMed
  19. Costa B, et al. 2019. Blood Adv. 3:1092. PubMed
RRID
AB_2129464 (BioLegend Cat. No. 303709)
AB_2249385 (BioLegend Cat. No. 303710)

Antigen Details

Structure
Integrin family, α subunit of CD41/CD61 (GPIIb-IIIa) complex, 125/22 kD
Distribution

Platelets, megakaryocytes

Function
Platelet aggregation, platelet attachment to extracellular matrix
Ligand/Receptor
Fibrinogen, fibronectin, von Willebrand factor, thrombin
Cell Type
Megakaryocytes, Platelets
Biology Area
Cell Adhesion, Cell Biology, Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Denzin L, et al. 1996. J. Exp. Med. 184:2153.
2. Denzin L, et al. 1995. Cell 82:155.
3. Riberdy J, et al. 1994. J. Cell Biol. 125:1225.

Gene ID
3674 View all products for this Gene ID
UniProt
View information about CD41 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11.30.2012

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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