APC anti-human CD207 (Langerin) Antibody

Pricing & Availability
10E2 (See other available formats)
Regulatory Status
Other Names
Mouse IgG1, κ
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Product Citations
Human monocytes derived Langerhans cells (stimulated with GM-CSF, IL-4 and TGF-β) were stained with CD1a PE and CD207 (clone 10E2) APC (top) or mouse IgG1, κ APC isotype control (bottom).
  • 10E2_APC_CD207_Antibody_FC_1_092012
    Human monocytes derived Langerhans cells (stimulated with GM-CSF, IL-4 and TGF-β) were stained with CD1a PE and CD207 (clone 10E2) APC (top) or mouse IgG1, κ APC isotype control (bottom).
  • 10E2_APC_CD207_Antibody_FC_2_092012
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352205 25 tests 120€
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352206 100 tests 290€
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CD207, also known as Langerin, is a 40 kD type II transmemberane cell glycoprotein which belongs to C-type lectin with mannose binding specificity. It is predominantly expressed on Langerhans cells and induces the formation of Birbeck granules, the Langerhans cell hallmark organelle. It is also found on several other subtypes of dendritic cells, such as dermal CD103-positive dendritic cells and splenic CD8-positive dendritic cells. Langerin is generally thought to be involved in antigen processing. Recently, it has been found that HIV captured by Langerin was internalized into Birbeck granule and degraded, which results in inhibition of HIV-1 infection and subsequent transmission.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Reported Reactivity
Antibody Type
Host Species
Primary human Langerhans cells
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported application (for the relevant formats) includes: blocking the binding of HIV-1 to Langerhans cells1.

Application References

(PubMed link indicates BioLegend citation)
  1. Witte LD, et al. 2007. Nat. Med. 13:367. (Block)
Product Citations
  1. Xu Y, et al. 2021. Cell Reports. 36(6):109524. PubMed
AB_2561589 (BioLegend Cat. No. 352205)
AB_2561590 (BioLegend Cat. No. 352206)

Antigen Details

40 kD glycoprotein

Langerhans cells, dermal CD103-positive dendritic cells, and splenic CD8-positive dendritic cells

Binding and processing antigen; capturing, internalizing and degrading HIV
Antigen containing mannose, N-acetyl glucosamine, and fucose
Cell Type
Dendritic cells, Langerhans cells
Biology Area
Immunology, Innate Immunity
Molecular Family
CD Molecules
Antigen References

1. Valladeau J, et al. 2000. Immunity 12:71.
2. Mc Dermott R, et al. 2002. Mol. Biol. Cell. 13:317.
3. Mizumoto N, et al. 2004. J. Clin. Invest. 113:701.
4. Witte LD, et al. 2007. Nat. Med. 13:367.

Gene ID
50489 View all products for this Gene ID
View information about CD207 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 04.19.2013

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.


*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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