- RCR-401 (See other available formats)
- Regulatory Status
- Other Names
- Endothelial protein C receptor, protein C receptor, PROCR, activated protein C receptor, APC receptor
- Rat IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
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Endothelial protein C receptor (EPCR), also known as CD201, is a 46 kD N-glycosylated type I transmembrane protein primarily expressed on the endothelial cells of arteries and veins in heart and lung. It is also expressed at high levels on a subset of hematopoietic stem cells and a subset of dendritic cells. CD201 functions as a primary receptor for protein C activation, which results in inhibition of both intrinsic and extrinsic coagulation pathways. It also plays an important role in many pathophysiologic processes, such as inflammation responses to infection, trauma, hematopoiesis, and autoimmune response. Deletion of the CD201 gene in knock-out mice leads to embryonic lethality before embryonic day 10, indicating that CD201 expression is critical for embryo development. In humans, mutations of CD201 have been associated with venous thromboembolism and myocardial infarction as well as with late fetal loss during pregnancy.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Red Laser (633 nm)
- Product Citations
AB_11142684 (BioLegend Cat. No. 351905)
AB_11126139 (BioLegend Cat. No. 351906)
- 46 kD of N-glycosylated type I transmembrane protein
Endothelial cells, subset of hematopoietic stem cells, subset of dendritic cells
- Inhibits blood coagulation, inflammation, and hematopoiesis
- Activated receptor1 (Par-1)
- Protease C
- Cell Type
- Dendritic cells, Endothelial cells, Hematopoietic stem and progenitors
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Costimulatory Molecules, Immunology
- Molecular Family
- CD Molecules
- Antigen References
1. Kerschen E, et al. 2010. J. Clin. Invest. 120:3167.
2. Iwasaki H, et al. 2010. Blood 116:544.
3. Balazs AB, et al. 2006. Blood 107:2317.
- Gene ID
- 10544 View all products for this Gene ID
- View information about CD201 on UniProt.org
Related Pages & Pathways
Other FormatsView All CD201 Reagents Request Custom Conjugation
|PE anti-human CD201 (EPCR)||RCR-401||FC|
|Purified anti-human CD201 (EPCR)||RCR-401||FC|
|APC anti-human CD201 (EPCR)||RCR-401||FC|
|TotalSeq™-A0069 anti-human CD201 (EPCR)||RCR-401||PG|
|TotalSeq™-C0069 anti-human CD201 (EPCR)||RCR-401||PG|
|TotalSeq™-B0069 anti-human CD201 (EPCR)||RCR-401||PG|
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