Loading...

APC anti-human CD105 Antibody

Pricing & Availability
Clone
43A3 (See other available formats)
Regulatory Status
RUO
Other Names
Endoglin
Isotype
Mouse IgG1, κ
Ave. Rating
Submit a Review
Product Citations
publications
43A3_APC_050707
Human monocytic cell line THP-1 stained with 43A3 APC
  • 43A3_APC_050707
    Human monocytic cell line THP-1 stained with 43A3 APC
Compare all formats See APC spectral data
Cat # Size Price Quantity Check Availability Save
323207 25 tests 120€
Check Availability


Need larger quantities of this item?
Request Bulk Quote
323208 100 tests 252€
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD105 is also known as Endoglin. It is a type I integral membrane homodimer protein with subunits of 90 kD found on vascular endothelial cells and syncytiotrophoblasts of placenta. CD105 is weakly expressed on stromal fibroblasts. It is also expressed on activated monocytes and tissue macrophages. Expression of CD105 is increased on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation. CD105 is a component of the TGF-β receptor system in human umbilical vein endothelial cells and binds TGF-β1 and β3 with high affinity but does not bind to TGF-β2.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
L-cells transfected with human CD105
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Bühring HJ, et al. 1991. Leukemia 5:841.
  2. Vogel W, et al. 2002. Haematologica 88:126.
  3. Osaka M, et al. 2011. Brain Res. 9:1343. PubMed
  4. HonMou O, et al. 2011. Brain. 134:1790. PubMed
  5. Herrera MB, et al. 2013. Hepatology. 57:311. PubMed
  6. Iohara K, et al. 2014. Exp Gerontol. 52:39. PubMed
Product Citations
  1. Laviola L, et al. 2012. Endocrinology. 153:5770. PubMed
  2. Radhakrishnan S, et al. 2019. Mol Med Rep. 20:813. PubMed
  3. Zhang Z, et al. 2021. Cell Death Dis. 12:644. PubMed
  4. Jiang S, et al. 2021. Bioact Mater. 2711:6. PubMed
  5. Han J, et al. 2022. FEBS J. 289:417. PubMed
  6. Leimkühler NB, et al. 2020. Cell Stem Cell. 28:637. PubMed
  7. Gao P, et al. 2017. Cytotechnology. 69:751. PubMed
  8. Li J, et al. 2021. Mol Med Rep. 1:23. PubMed
  9. Di Stefano B, et al. 2019. Cell Stem Cell. 25:622. PubMed
  10. Nelson L, et al. 2020. Nat Commun. 1.029166667. PubMed
  11. Okamura G, et al. 2020. Int J Mol Sci. 22:00. PubMed
  12. Sielatycka K, et al. 2017. Stem Cell Rev. 1.079166667. PubMed
  13. Liu T, et al. 2019. Front Endocrinol (Lausanne). 10:360. PubMed
  14. Chijimatsu R, et al. 2022. Regen Ther. 21:52. PubMed
  15. Gu S, et al. 2016. Sci Rep. 6:23287. PubMed
  16. Thiel A, et al. 2015. Sci Rep. 5: 17685. PubMed
RRID
AB_755959 (BioLegend Cat. No. 323207)
AB_755960 (BioLegend Cat. No. 323208)

Antigen Details

Structure
Associates with TGF-ß receptor I and II, homodimeric type I integral membrane protein, 90 kD
Distribution

Endothelial cells, activated monocytes/macrophages, bone marrow stromal cells, hematopoietic stem/progenitor cells

Function
Modulates cellular response to TGF-ß, involved in vascular development and remodelling
Ligand/Receptor
TGF-ß1, TGF-ß3
Cell Type
Endothelial cells, Hematopoietic stem and progenitors, Macrophages, Mesenchymal Stem Cells, Monocytes
Biology Area
Angiogenesis, Cell Biology, Immunology, Stem Cells
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Mason D, et al. Eds. 2002. Leucocyte Typing VII. Oxford University Press. New York.
2. Pierelli L, et al. 2001. Leuk. Lymphoma 42:1195.

Gene ID
2022 View all products for this Gene ID
UniProt
View information about CD105 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11.30.2012

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

  • Purified anti-human CD105

  • FITC anti-human CD105

  • PE anti-human CD105

  • APC anti-human CD105

  • Alexa Fluor® 488 anti-human CD105

  • Alexa Fluor® 647 anti-human CD105

  • Biotin anti-human CD105

  • PerCP/Cyanine5.5 anti-human CD105

  • PE/Cyanine7 anti-human CD105

  • Brilliant Violet 421™ anti-human CD105

  • TotalSeq™-A0068 anti-human CD105

  • PE/Dazzle™ 594 anti-human CD105

  • TotalSeq™-C0068 anti-human CD105

  • TotalSeq™-B0068 anti-human CD105

  • APC/Fire™ 750 anti-human CD105 Antibody

  • TotalSeq™-D0068 anti-human CD105

ProductsHere
Login / Register
Remember me
Forgot your password? Reset password?
Create an Account