- BL168 (See other available formats)
- Regulatory Status
- Other Names
- Interleukin IL-17A, IL-17, Cytotoxic T lymphocyte-associated antigen 8 (CTLA-8)
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
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IL-17A is the founding member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A, secreted by activated CD4+ Th17 cell subpopulation, elicits multiple biological activities on a variety of cells including: the induction of IL-6, IL-8, G-CSF, and PGE2 production in epithelial, endothelial or fibroblasts; the enhancement of surface expression of ICAM-1 in fibroblasts; activation of NF-κB and costimulation of T cell proliferation. Recent studies demonstrated that, in mice, activated IL-17-secreting CD4+ helper T cells (Th17 cells) mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA). Human IL-17A shows 63%, 63%, and 72% amino acid sequence identity to rat IL-17A, mouse IL-17A, and a protein encoded by the ORF13 gene of herpesvirus Saimiri (HVS), respectively.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Recombinant full length human IL-17A
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 700 under optimal conditions.
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. It is highly recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 700 has a maximum emission of 719 nm when it is excited at 633nm / 635nm. Prior to using Alexa Fluor® 700 conjugate for flow cytometric analysis, please verify your flow cytometer's capability of exciting and detecting the fluorochrome.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
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- Excitation Laser
Red Laser (633 nm)
- Product Citations
AB_2280255 (BioLegend Cat. No. 512317)
AB_2124868 (BioLegend Cat. No. 512318)
- Cytokine; dimer; ~15 kD (Mammalian)
- Secretion of IL-6, IL-8, G-CSF, prostaglandin E2 by epithelial, endothelial or fibroblastic cells; stimulates cell migration, cord formation, and IL-6 secretion by stromal cells
- Cell Sources
- Activated T cell subpopulation
- Cell Targets
- Fibroblasts, epithelial and endothelial cells, stromal cells
- Cell Type
- Biology Area
- Cell Biology, Immunology, Neuroinflammation, Neuroscience
- Molecular Family
- Antigen References
1. Hirota K, et al. 2007. J. Exp. Med. 204:41.
2. Furuzawa-Carballeda J, et al. 2007. Autoimmun. Rev. 6:169.
3. Witowski J, et al. 2007. Kidney Int. 71:514.
4. Gaffen SL, et al. 2006. Vitam. Horm. 74:255.
5. Hymowitz S, et al. 2001. EMBO J. 20:5332.
- Gene ID
- 3605 View all products for this Gene ID
- View information about IL-17A on UniProt.org
Related Pages & Pathways
Other FormatsView All IL-17A Reagents Request Custom Conjugation
|Brilliant Violet 421™ anti-human IL-17A||BL168||ICFC|
|Purified anti-human IL-17A||BL168||ICFC|
|FITC anti-human IL-17A||BL168||ICFC|
|PE anti-human IL-17A||BL168||ICFC|
|Alexa Fluor® 488 anti-human IL-17A||BL168||ICFC|
|Alexa Fluor® 647 anti-human IL-17A||BL168||ICFC|
|Pacific Blue™ anti-human IL-17A||BL168||ICFC|
|PerCP/Cyanine5.5 anti-human IL-17A||BL168||ICFC|
|PE/Cyanine7 anti-human IL-17A||BL168||ICFC|
|Alexa Fluor® 700 anti-human IL-17A||BL168||ICFC|
|APC/Cyanine7 anti-human IL-17A||BL168||ICFC|
|Brilliant Violet 570™ anti-human IL-17A||BL168||ICFC|
|Brilliant Violet 605™ anti-human IL-17A||BL168||ICFC|
|Brilliant Violet 711™ anti-human IL-17A||BL168||ICFC|
|Brilliant Violet 510™ anti-human IL-17A||BL168||ICFC|
|APC anti-human IL-17A||BL168||ICFC|
|Purified anti-human IL-17A (Maxpar® Ready)||BL168||ICFC,CyTOF®|
|PE/Dazzle™ 594 anti-human IL-17A||BL168||ICFC|
|Brilliant Violet 785™ anti-human IL-17A||BL168||ICFC|
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Brilliant Violet 421™ anti-human IL-17A
Purified anti-human IL-17A
FITC anti-human IL-17A
PE anti-human IL-17A
Alexa Fluor® 488 anti-human IL-17A
Alexa Fluor® 647 anti-human IL-17A
Pacific Blue™ anti-human IL-17A
PerCP/Cyanine5.5 anti-human IL-17A
PE/Cyanine7 anti-human IL-17A
Alexa Fluor® 700 anti-human IL-17A
APC/Cyanine7 anti-human IL-17A
Brilliant Violet 570™ anti-human IL-17A
Brilliant Violet 605™ anti-human IL-17A
Brilliant Violet 711™ anti-human IL-17A
Brilliant Violet 510™ anti-human IL-17A
APC anti-human IL-17A
Purified anti-human IL-17A (Maxpar® Ready)
PE/Dazzle™ 594 anti-human IL-17A
Brilliant Violet 785™ anti-human IL-17A