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Alexa Fluor® 647 anti-human IL12RB2 Antibody

Pricing & Availability
Clone
S16020B (See other available formats)
Regulatory Status
RUO
Other Names
Interleukin-12 receptor subunit beta-2
Isotype
Mouse IgG2a, κ
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Product Citations
publications
S16020B_A647_IL12RB2-_Antibody_091521.png
Human peripheral blood lymphocytes were activated for 3 days with PHA, and then stained with IL12RB2 (clone S16020b) (filled histogram) Alexa Fluor® 647 or mouse IgG2a, κ Alexa Fluor® 647 isotype control (open histogram).
  • S16020B_A647_IL12RB2-_Antibody_091521.png
    Human peripheral blood lymphocytes were activated for 3 days with PHA, and then stained with IL12RB2 (clone S16020b) (filled histogram) Alexa Fluor® 647 or mouse IgG2a, κ Alexa Fluor® 647 isotype control (open histogram).
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394207 25 tests 151€
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394208 100 tests 320€
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Description

IL12RB2 is a type I transmembrane protein that foms an heterodimer with IL12RB1 to produce the high affinity IL-12 receptor complex. IL12RB2 is expressed by activated T cells, TH1 cells, NK cells, B cells and plasma cells. Variants of this gene are associated with predisposition to various immune-related diseases.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human IL12RB2 transfected cells.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.


Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.

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Excitation Laser
Red Laser (633 nm)
RRID
AB_2894595 (BioLegend Cat. No. 394207)
AB_2894595 (BioLegend Cat. No. 394208)

Antigen Details

Structure
Type I transmembrane protein, 3 isoforms, foms an heterodimer with IL12RB1
Distribution

Activated T cells, TH1 cells, NK cells, B cells,  plasma cells

Function
Role in TH1 differentiation
Ligand/Receptor
IL-12
Cell Type
B cells, NK cells, Plasma cells, T cells, Th1
Biology Area
Immunology
Molecular Family
Cytokine/Chemokine Receptors
Antigen References
  1. LaMere SA, et al. 2017. J Immunol. 199:3158
  2. Prigione I, et al. 2016. Immunobiology. 221:291
  3. de Paus RA, et al. 2013. Mol Immunol. 56:380
  4. Airoldi I, et al. 2008. Blood. 112:750
Gene ID
3595 View all products for this Gene ID
UniProt
View information about IL12RB2 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 09.15.2021

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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