- MWReg30 (See other available formats)
- Regulatory Status
- Other Names
- Fibrinogen receptor, gpIIb/IIIa, integrin alpha IIb, CD41a
- Rat IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
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CD41, also known as integrin α2b and GPIIb, is a transmembrane glycoprotein that is expressed by platelets and megakaryocytes. It was reported that CD41 is also expressed on hematopoietic progenitors. CD41 associates with CD61 (integrin β3) to form complexes that interact with fibrinogen, fibronectin, von Willebrand factor, and thrombin. CD41 is required for platelet adhesion and aggregation. Defect of CD41 leads to disorders of coagulation.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Mouse platelets
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 488 has a maximum emission of 519 nm when it is excited at 488 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
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- Excitation Laser
Blue Laser (488 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: depletion of platelets and functional assay in vivo.4,7 The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for in vivo studies (Cat. No. 133939).
(PubMed link indicates BioLegend citation)
- Nieswandt B, et al. 1999. Blood 94:684.
- Teeling JL, et al. 2001. Blood 98:1095.
- Bertrand JY, et al. 2005. P. Natl. Acad. Sci. USA 102:134.
- Nocito A, et al. 2007. Hepatology 45:369. (Deplete)
- Sullivan BP, et al. 2010. Toxicol. Sci. 115:286. (Deplete) PubMed
- van der Heyde HC, et al. 2005. Blood 105:1956. (FA)
- Marjon KD, et al. 2009. J. Immunol. 182:1397. (Deplete)
- Product Citations
AB_10639937 (BioLegend Cat. No. 133907)
AB_10645332 (BioLegend Cat. No. 133908)
- A transmembrane glycoprotein that is expressed by platelets and megakaryocytes
Platelets, megakaryocytes, and hematopoietic progenitors
- Associate with CD61 (integrin β3) to form a complex which plays a major role in platelet adhesion and aggregation
- Fibrinogen, fibronectin, von Willebrand factor, thrombin
- Cell Type
- Hematopoietic stem and progenitors, Megakaryocytes, Platelets
- Biology Area
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
1. Bakewell SJ, et al. 2003. P. Natl. Acad. Sci. USA 100:14205.
2. Phillips DR, et al. 1991. Cell. 65:359.
- Gene ID
- 16399 View all products for this Gene ID
- View information about CD41 on UniProt.org
|Brilliant Violet 421™ anti-mouse CD41||MWReg30||FC|
|Purified anti-mouse CD41||MWReg30||FC, FA|
|FITC anti-mouse CD41||MWReg30||FC|
|PE anti-mouse CD41||MWReg30||FC|
|Alexa Fluor® 488 anti-mouse CD41||MWReg30||FC|
|APC anti-mouse CD41||MWReg30||FC|
|PE/Cyanine7 anti-mouse CD41||MWReg30||FC|
|PerCP/Cyanine5.5 anti-mouse CD41||MWReg30||FC|
|Brilliant Violet 605™ anti-mouse CD41||MWReg30||FC|
|Brilliant Violet 510™ anti-mouse CD41||MWReg30||FC|
|Purified anti-mouse CD41 (Maxpar® Ready)||MWReg30||FC, CyTOF®|
|APC/Cyanine7 anti-mouse CD41||MWReg30||FC|
|Alexa Fluor® 700 anti-mouse CD41||MWReg30||FC|
|Biotin anti-mouse CD41||MWReg30||FC|
|Pacific Blue™ anti-mouse CD41||MWReg30||FC|
|Alexa Fluor® 647 anti-mouse CD41||MWReg30||FC|
|PE/Dazzle™ 594 anti-mouse CD41||MWReg30||FC|
|TotalSeq™-A0443 anti-mouse CD41||MWReg30||PG|
|Ultra-LEAF™ Purified anti-mouse CD41||MWReg30||FC, FA|
|TotalSeq™-B0443 anti-mouse CD41||MWReg30||PG|
|TotalSeq™-C0443 anti-mouse CD41||MWReg30||PG|
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Brilliant Violet 421™ anti-mouse CD41
Purified anti-mouse CD41
FITC anti-mouse CD41
PE anti-mouse CD41
Alexa Fluor® 488 anti-mouse CD41
APC anti-mouse CD41
PE/Cyanine7 anti-mouse CD41
PerCP/Cyanine5.5 anti-mouse CD41
Brilliant Violet 605™ anti-mouse CD41
Brilliant Violet 510™ anti-mouse CD41
Purified anti-mouse CD41 (Maxpar® Ready)
APC/Cyanine7 anti-mouse CD41
Alexa Fluor® 700 anti-mouse CD41
Biotin anti-mouse CD41
Pacific Blue™ anti-mouse CD41
Alexa Fluor® 647 anti-mouse CD41
PE/Dazzle™ 594 anti-mouse CD41
TotalSeq™-A0443 anti-mouse CD41
Ultra-LEAF™ Purified anti-mouse CD41
TotalSeq™-B0443 anti-mouse CD41
TotalSeq™-C0443 anti-mouse CD41